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. 2015 Dec 11;16(12):29682–29716. doi: 10.3390/ijms161226191

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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Scheme 4 — Synthesis of Pregabalin intermediates through kinetic enzymatic hydrolysis of (a) rac-γ-nitro esters [13] and (b) rac-2-carboxyethyl-3-cyano-5-methylhexanoic acid ethyl ester [14].