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. 2015 Dec 18;16(12):30204–30222. doi: 10.3390/ijms161226230

Figure 1.

Figure 1

Functional characterization of miRNAs in a condition-specific manner by data-driven inference of mi-/mRNA networks and subsequent functional annotation in the networks. (A) MiRlastic uses a two-step approach integrating prior knowledge and mi-/mRNA expressions to infer mi-/mRNA network and miRNA functional annotation; (B) Schematic drawing of miRNAs co-expressed in clusters induced by an yet unknown regulatory layer. Only several of the putative miRNA regulators are collectively regulating the mRNA expression.