. 2015 Dec 18;16(12):30321–30341. doi: 10.3390/ijms161226232

Table 2.

Phenotypes of cFLIP gene-manipulated mice.

	Genotype/Organ	Phenotype	References
Whole body KO mice	Cflip^−/−	Embryonic lethality	[82]
	Cflip-l+46 mutant	Embryonic lethality	[83]
	Cflip^−/−Ripk3^−/−	Embryonic lethality	[84]
	Cflip^−/−Fadd^−/−Ripk3^−/−	Normal development	[84]
Conditional KO mice	T cells	Increased cell death	[85,86,87,88]
	B cells	Increased cell death	[89,90]
	Myeloid lineage	Growth retardation, Splenomegaly	[91,92]
	Dendritic cells	Increased inflammation	[93,94]
	Liver	Increased liver failure	[95,96,97,98,99,100]
	Intestine	Increased cell death and inflammation	[95,101]
	Skin epidermis	Increased cell death and inflammation	[102,103]
Transgenic mice	cFLIP_R in Cflip-deficient T cells	Similar to Cflip-deficient T cells	[104,105]
	cFLIP_L in T cells	Increased survival	[106,107,108,109,110,111,112,113,114,115]
	cFLIP_S in T cells	Increased survival	[116,117]
	cFLIP_L in neuron	Increased survival	[118]
	cFLIP_L in thyroid	Better resolution from autoimmune disease	[119,120,121,122]
	cFLIP_L in heart	Reduced cardiac hypertrophy, prevention of cardiac remodeling	[123,124,125]
	cFLIP_L in eosinophil	Increased survival	[126]
	cFLIP_L in testis	Testis atrophy	[127]
	cFLIP_L in muscle	Muscle aging	[128]
	cFLIP_R in hematopoietic cells	Better bacterial clearance, increased autoimmune disease	[129,130]