Table 2.
Association between clinicopathologic characteristics and OCT4 or SOX2 expression
| OCT4 | SOX2 | |||
|---|---|---|---|---|
| Mean Histoscore (95 % CI) | p value | Mean Histoscore (95 % CI) | p value | |
| Diagnostic category | <0.001 | <0.001 | ||
| Normal | 113.3 (105.1–121.4) | 36.5 (32.3–40.8) | ||
| Low-grade CIN | 197.6 (177.4–217.7) | 40.0 (28.8–51.2) | ||
| High-grade CIN | 219.0 (211.3–226.8) | 91.7 (79.9–103.5) | ||
| Cancer | 208.5 (196.7–220.3) | 105.4 (91.8–119.1) | ||
| FIGO stage | 0.498 | 0.529 | ||
| < IIA | 205.7 (191.6–219.7) | 108.1 (92.1–124.2) | ||
| > IIB | 215.1 (192.6–237.6) | 98.3 (71.5–125.1) | ||
| Tumor differentiation | 0.438 | 0.112 | ||
| Well + moderate | 203.8 (187.7–219.8) | 112.8 (94.4–131.1) | ||
| Poor | 213.4 (195.3–231.4) | 90.1 (69.0–111.3) | ||
| Cell type | 0.450 | 0.060 | ||
| SCC | 205.8 (192.4–219.2) | 111.7 (96.4–127.0) | ||
| Other | 217.2 (190.8–243.6) | 78.3 (69.0–111.3) | ||
| Tumor size | 0.868 | 0.015 | ||
| ≤ 4 cm | 208.7 (194.2–223.2) | 116.5 (100.1–132.8) | ||
| > 4 cm | 206.5 (185.5–227.6) | 80.3 (56.3–104.2) | ||
| LVSI | 0.045 | 0.106 | ||
| No | 195.3 (175.8–214.8) | 115.5 (95.4–135.6) | ||
| Yes | 220.1 (205.3–234.9) | 91.8 (71.2–112.5) | ||
| LN metastasis | 0.206 | 0.879 | ||
| No | 202.6 (187.1–218.0) | 105.6 (88.6–122.7) | ||
| Yes | 221.0 (199.7–242.3) | 103.1 (75.6–130.6) | ||
| HPV test in CIN | 0.292 | 0.907 | ||
| Negative | 246.8 (223.7–215.7) | 124.9 (81.5–168.7) | ||
| Positive | 227.9 (215.7–240.1) | 127.6 (110.5–144.6) |
SCC squamous cell carcinoma, AD adenocarcinoma, LVSI lymphovascular space invasion, LN lymph node, HPV human papillomavirus