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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Hepatol. 2015 Jul 26;64(1):44–52. doi: 10.1016/j.jhep.2015.07.022

Figure 1. Frequent induction of STS in chronic inflammatory liver diseases, and increased estrogen levels in patients of alcoholic cirrhosis.

Figure 1

(A) Hepatic mRNA expression of STS (left), EST (middle) and IL-8 (right) in patients with normal or elevated CRP (GSE32504)as determined by real-time PCR. (B) Hepatic mRNA expression of STS (left), CYP3A4, CYP1A2 and EST (middle left) and IL-8 (middle right), and correlation between the expression of IL-8 and STS (right) in control subjects and patients with alcoholic hepatitis (GSE28619). (C) IHC analysis of STS expression. The top panels are representative cases showing STS expression in control, hepatitis and cirrhosis patients. The bottom panels are corresponding controls without the use of primary anti-STS antibody. (D) Serum level of estrone (left) and estrone sulfate (right) in control subjects and patients with alcoholic cirrhosis from the University of Louisville Hospitals. (E) The mRNA expression of STS in human primary hepatocytes treated with vehicle (VEH), LPS (1 μg/mL), Ethanol (EtOH, 100 μM) or LPS + Ethanol for 6 h. *, P<0.05; **, P<0.01; ***, P<0.001; NS, statistically not significant.