Skip to main content
. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Hepatol. 2015 Aug 29;64(1):118–127. doi: 10.1016/j.jhep.2015.08.019

Fig. 7. Liver injury in knockout mice is blocked by an IL-1Ra.

Fig. 7

(A) Serum ALT levels in C57BL6 mice pretreated with normal saline (NS) or IL-1Ra 6 h after GalN/LPS administration (*P<0.04 as compared to normal saline; n=6). (B) Serum ALT levels in Atg5Δmye mice pretreated with normal saline (NS) or IL-1Ra at the indicated times after GalN/LPS (*P<0.004 as compared to normal saline; n=6-7). (C) Numbers of TUNEL positive cells per high power field (*P<0.03, **P<0.002, as compared to normal saline; n=3-5). (D) Percentage survival (P<0.001; n=18-21). (E-H) Hepatic mRNA levels at 5 and 6 h for (E) NOS2 (*P<0.02), (F) COX2 (*P<0.02), (G) IL-1β (*P<0.002), and (H) IFNγ (*P<0.04) (n=5-7). (I) Hepatic TNF mRNA levels at 1 and 4 h (n=3). (J) Serum TNF levels in the same mice (n=3). (K) Number of CD68 positive cells in untreated (Ø) and 4 h post-GalN/LPS-treated livers (*P<0.005 as compared to normal saline; n=3-6). (L) Numbers of Ly6G positive staining cells in the same livers (n=3-6).