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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Alcohol. 2015 Oct 27;49(8):781–794. doi: 10.1016/j.alcohol.2015.08.006

Fig. 7. CB1 agonists modulate ethanol effects on sIPSCs in BLA slices from adult rats.

Fig. 7

A) sIPSC frequency plotted as a function of time during an experiment in which the CB1 agonist WIN 55,212 (5 μM) was applied to BLA slices prior to application of 80-mM ethanol. The agonist reduced sIPSC frequency and abolished potentiation by ethanol. B) Bar graph showing the effect of ethanol alone as well as ethanol + WIN in the modulation of sIPSC frequency. (*p < 0.05 vs. baseline, paired t test). C) Graph showing normalized sIPSC frequency over time before, during, and after depolarization using our standard CsCl (open circles), in the presence of 80-mM ethanol (closed squares) and after ethanol washout (open triangles). D) Bar graphs show the DSI effect on sIPSC frequency during the first 15 sec after DSI, using our standard CsCl, in the presence of ethanol and after ethanol washout (*p < 0.05 vs. baseline, paired t test).