Skip to main content
BioMed Research International logoLink to BioMed Research International
. 2015 Dec 13;2015:746560. doi: 10.1155/2015/746560

Complications Associated with the Use of Supraglottic Airway Devices in Perioperative Medicine

Pavel Michalek 1,2,*, William Donaldson 3, Eliska Vobrubova 1, Marek Hakl 4
PMCID: PMC4691459  PMID: 26783527

Abstract

Supraglottic airway devices are routinely used for airway maintenance in elective surgical procedures where aspiration is not a significant risk and also as rescue devices in difficult airway management. Some devices now have features mitigating risk of aspiration, such as drain tubes or compartments to manage regurgitated content. Despite this, the use of these device may be associated with various complications including aspiration. This review highlights the types and incidence of these complications. They include regurgitation and aspiration of gastric contents, compression of vascular structures, trauma, and nerve injury. The incidence of such complications is quite low, but as some carry with them a significant degree of morbidity the need to follow manufacturers' advice is underlined. The incidence of gastric content aspiration associated with the devices is estimated to be as low as 0.02% with perioperative regurgitation being significantly higher but underreported. Other serious, but extremely rare, complications include pharyngeal rupture, pneumomediastinum, mediastinitis, or arytenoid dislocation. Mild short-lasting adverse effects of the devices have significantly higher incidence than serious complications and involve postoperative sore throat, dysphagia, pain on swallowing, or hoarseness. Devices may have deleterious effect on cervical mucosa or vasculature depending on their cuff volume and pressure.

1. Introduction

Supraglottic airway devices (SGAs) are tools used for airway management in anesthesia and also in certain situations outside the operating room [1]. They are less invasive than endotracheal tubes, which is attributed to their positioning outside of the larynx. Several classifications of these devices have been proposed: based on the absence or presence of a drainage channel, site and mechanism of sealing, or other features [2, 3]. The most commonly used classification divides the SGAs into 1st-generation devices containing only a breathing lumen (Figure 1) and 2nd-generation SGAs (Figure 2), which possess an additional channel for drainage of gastric contents.

Figure 1.

Figure 1

Main commercially available SGA devices without separated gastric channel (1st generation). (a) LMA Classic, (b) LMA Flexible, (c) LM Solus, (d) LM Portex Soft Seal, (e) LM AuraOnce, (f) Cobra PLA, (g) LMA Fastrach, (h) LM Aura-i, and (i) air-Q intubating laryngeal airway. Last three devices are designated as conduits for tracheal intubation.

Figure 2.

Figure 2

Main SGA devices with a mechanism for drainage of gastric contents (2nd generation). (a) ProSeal LMA, (b) Supreme LMA, (c) Laryngeal Tube Suction-D, (d) i-gel, (e) SLIPA, (f) Baska mask, and (g) AuraGain LM.

Another logical classification relates the sealing site of SGAs and may be divided into base-of-tongue (BT) or pharyngeal sealers and perilaryngeal (PL) sealers [3]. Base-of-tongue sealers were invented more than 65 years ago, when Leech introduced his “pharyngeal bulb gasway” in 1937 [4]. The second line of SGAs, perilaryngeal sealers, was derived from the classical laryngeal mask airway (LMA Classic, cLMA), invented by Brain and patented in the UK in 1982 (GB2111394A) [5]. Various devices, described in Table 1, have been invented and introduced into clinical practice since 1992. Modern SGAs are disposable, withstand high seal pressures, are easy to insert with a high success rate more than 95%, and possess a mechanism for separation of respiratory and gastrointestinal tracts [4].

Table 1.

Main commercially available SGAs divided into the devices without and with aspiration protection mechanism and according to the sealing mechanism [4], (I)—may be used as a conduit for an insertion of tracheal tube. LTS-D: Laryngeal Tube Suction device, PLA: perilaryngeal airway, LMA: laryngeal mask airway, LM: laryngeal mask, ILA: intubating laryngeal airway, and SLIPA: Streamlined Liner of Pharyngeal Airway. SALT: Supraglottic Airway Laryngopharyngeal Tube.

Aspiration protection Base-of-tongue (BT) sealers Perilaryngeal (PL) sealers
None (1st generation) VBM Laryngeal Tube (VBM, Germany)
King Laryngeal Tube (King System, USA)
Cobra PLA (Pulmodyne, USA)
Cobra Plus (Pulmodyne, USA)
LMA Classic (LMA Co., Seychelles)
LMA Unique (LMA Co., Seychelles)
LMA Flexible (LMA Co., Seychelles)
LMA Classic Excel (I) (LMA Co., Seychelles)
AuraOnce LM (Ambu, Denmark)
Aura-i LM (I) (Ambu, Denmark)
Portex Soft Seal (Smith Med., UK)
Solus LM (Intersurgical, UK)
Sheridan LM (Teleflex, USA)
La Premiere Plus LM, LaEncore Plus LM (Armstrong Medical, UK)
Vital Seal LM (GE Healthcare, USA)
Ultra CPV (AES, USA)
Intubating LMA, Fastrach (I) (LMA Co., Seychelles)
CTrach LMA (I) (LMA Co., Singapore)
Air-Q ILA (I) (Mercury Medical, USA)

Gastric channel or storage container (2nd generation) Combitube (Covidien, USA)
Rusch Easy Tube (Teleflex, USA)
VBM LTS II (VBM, Germany)
King LTS-D (King System, USA)
SLIPA (CurveAir, UK)
SALT (I) (Ecolab, USA)
LMA ProSeal (LMA Co., Seychelles)
LMA Supreme (LMA Co., Seychelles)
i-gel (I) (Intersurgical, UK)
Aura Gain LM (I) (Ambu, Denmark)
Guardian LMA (Ultimate Medical, Australia)

Gastric channel + self-energizing mechanism of seal Baska mask (I) (Logikal Health Products, Australia)
3gLM (I) (CurveAir, UK)

Initially, SGAs were used mainly for maintenance of a patent airway during elective procedures under general anesthesia but, during years following the release of the prototypical cLMA, these devices have also found other areas of utilization, for example, as conduits for tracheal intubation in difficult laryngoscopy scenarios [6] or as airway adjuncts in cardiac arrest or in prehospital medicine [7]. Several review articles have focused on individual devices and particular clinical indications for their use but none has been targeted specifically at complications associated with their insertion.

2. Complications

The use of supraglottic airway devices (SGAs) in perioperative medicine is now widespread. The 4th National Audit Project (NAP4), which was conducted in the United Kingdom, estimated that 56% of general anaesthetics performed were carried out using SGAs to manage the airway [8]. This project, led by the Royal College of Anaesthetists, looked into complications of airway management in general in the United Kingdom. In all, 33 of the events that were reported to NAP4 involved SGAs [9]. These events included aspiration, airway trauma, loss of the airway on insertion, failed insertion, displacement after insertion, loss of airway during maintenance, and extubation-related problems. In most cases, multiple factors such as obesity, comorbidities, traumatic insertion, inappropriate use of the devices, low operator experience, nonstandard patient positioning, or shallow anesthesia contributed significantly to these complications.

Cheon et al. found that the overall incidence of complications depends on a patient's body mass index (BMI) and also on their age—obese patients with a BMI over 30 kg·m−2 and those older than 46 years have a significantly higher chance of developing difficulties with ventilation and intraoperative laryngospasm [10].

Most reports dealing with the complications associated with the SGAs come from their use in elective procedures. However, the SGAs are also integral part of difficult airway management and recommended back-up plan in failed intubation according to the guidelines of various societies (Difficult Airway Society, American Society of Anesthesiologist, French National Society of Anesthesiology). These scenarios involve emergency procedures in nonfasted patients and in those with significantly increased risk for aspiration of gastric contents and therefore the incidence of complications should be theoretically multiplied to the elective use of these devices. Nevertheless, any of large cohorts describing the use of ILMA [11] or other SGAs [12] in difficult airway patients did not look specifically at the complication rate.

Complications discussed in this paper include those with serious sequelae such as aspiration of gastric contents, trauma, nerve injuries, and compression of vascular structures and also minor adverse effects such as hoarseness, sore throat, or swallowing difficulties.

2.1. Aspiration of Gastric Contents

Regurgitation of gastric contents is a process that can occur under anesthesia and which may lead to pulmonary aspiration. Pulmonary aspiration of gastric content can be defined as the inhalation of material into the airway below the level of the vocal cords. Depending on the nature, volume, and pH of the material inhaled patients can suffer morbidity and even mortality. The prevention of aspiration is one of the hallmarks of safe practice in anesthesia.

The incidence of regurgitation under anaesthesia is unknown but the incidence of pulmonary aspiration has been described as between 0.01 and 0.06% in general [14]. Aspiration during anesthesia accounts for between 2.6% and 3.5% of cases in surveillance studies and closed claims analyses [15, 16] with no such claims relating to aspiration during LMA anesthesia [17]. NAP4 featured aspiration as the primary event in 17% of cases and was the commonest etiology for death and brain damage [9].

2.1.1. Aspiration and the 1st-Generation Perilaryngeal Sealers

The LMA Classic (cLMA) is the most studied SGA with over 2500 publications. A publication resulting from evaluation of one of the prototypes noted that there were no signs of regurgitation in 100 patients [18].

The first published case of significant aspiration leading to pneumonia was reported in 1990 [19]. This prompted a series of similar cases [20]. In reply to Nanji and Maltby's case report and an accompanying editorial, Dr. Brain—the inventor of the cLMA—pointed out that the patient described in the case report was unsuitable for use of the cLMA and also highlighted tips for reducing the risk of regurgitation, recognizing the problem and a treatment algorithm [21].

A large meta-analysis of publications describing aspiration and the cLMA by Brimacombe reported that the incidence of pulmonary aspiration with the cLMA was 2.3 per 10000 cases, which was comparable to the rates with endotracheal intubation or facemask anesthesia [22]. Two large studies also report low rates of aspiration with the device: 1 case in 11910 patients [23] and 3 cases in 35620 patients in a study which showed a similar incidence when compared with endotracheal intubation [24].

The mortality associated with aspiration and anesthesia is estimated to be 5% [25, 26]. Despite this, before completion of NAP4, only two deaths had been reported following aspiration with a cLMA [9, 27, 28].

Overall, the risk of aspiration for the cLMA is low and comparable to that seen with anesthesia using other devices to maintain the airway. No relevant data is available for the other laryngeal masks of the 1st generation such as the LMA Flexible, Intubating LMA Fastrach, AuraOnce, Aura-i, and La Premiere.

2.1.2. Aspiration and the 1st-Generation Base-of-Tongue (Pharyngeal) Sealers

These devices include the Laryngeal Tube (King LT) and Cobra Perilaryngeal Airway. Other devices from this group, Combitube and Easy Tube, are used mainly in prehospital medicine. Miller and Light suggested that the storage capacity of the Laryngeal Tube for regurgitated gastric contents inside the pharynx is higher than in cLMA, which may decrease the risk for aspiration with this device [29]. The safety of another SGA from this group (Cobra PLA) was questioned in a report by Cook and Lowe—they had to halt their study after two cases of aspiration (with an incidence of 6.9%) [30]. They highlighted that the device does not possess any mechanism for aspiration protection or obstruction of the esophagus. One of these two aspirations of gastric contents was reported during rotation of a malpositioned device during laparoscopic surgery.

2.1.3. Aspiration and the 2nd-Generation Devices

These devices fall into two subcategories: devices with a dedicated second gastric channel (LMA ProSeal (PLMA), LMA Supreme (SLMA), Laryngeal Tube Suction II (LTS II), i-gel, Baska Mask, AuraGain, and 3gLM) and devices designed to trap and store regurgitated material (SLIPA).

The PLMA has been described in several cases where it served to protect the airway from regurgitated content [31]. Despite this, there exist a number of cases describing aspiration associated with use of the device [3234].

The ProSeal requires careful positioning in order to function correctly, and if this is not the case then the device may actually increase the risk of regurgitation by contributing to gastric insufflation [33]. It is recommended that the position should be checked by following the manufacturer's recommendations or by the passage of a gastric tube. Novel techniques have been described for insertion using the gum-elastic bougie [35], gastric tubes [36], and suction catheters [37]. Less experienced users may benefit from the gastric tube-guided insertion of the PLMA [38].

The Laryngeal Mask Airway Supreme (SLMA) is a newer device with very little evidence of regurgitation associated with its use and no described cases of aspiration. A recent meta-analysis showed very low incidence of complications [39] and a large observational study of 700 patients undergoing caesarean section found no cases of aspiration [40].

The i-gel differs from the devices described above in that it has a cuff that does not require inflation. The i-gel also possesses a separate gastric channel. Despite, and in some cases because of, these features there have been cases described in the literature of both regurgitation and aspiration of gastric contents: Gibbison et al. described a case series of three patients who regurgitated under anesthesia [41]. In two of these cases, the authors stated that the i-gel protected the patients from aspiration. The third case did aspirate, but with no complications, and was discharged the same day. The authors state that the drain tube allowed recognition of regurgitation, which they suggest may have gone undiscovered with the use of a first-generation device. They conclude that the incidence of regurgitation and aspiration for the device is low and noted that—at the time—no patients appeared to have come to harm from such episodes. This phenomenon of “recognition of regurgitation” is also described in a case by Liew et al. [42].

The i-gel has been found to have a lower esophageal seal than both the cLMA and PLMA, but together with the PLMA it was found to drain away regurgitated fluid effectively [43]. The lower esophageal seal is likely due to the fact that the tip of the i-gel is narrower—which was a deliberate design intended to decrease dysphagia associated with SGAs [3].

The SLIPA, LTS-II, and its disposable version LTS-D have no published reports referring to either regurgitation or aspiration.

There is still a lack of high-quality evidence associated with those SGAs with an incorporated gastric channel with regard to their ability to deal with the risk of regurgitation and aspiration and large, well-conducted trials are needed in this area. Despite this lack of evidence, the authors of NAP4 made recommendations regarding the use of 2nd-generation SGAs, including the following: “If tracheal intubation is not considered to be indicated but there is some (small) increased concern about regurgitation risk a second generation supraglottic airway is a more logical choice than a first generation one.” Similar recommendation has been also published in a recent editorial [44].

2.2. Trauma

Microscopic trauma associated with insertion of SGAs is thought to be relatively common but of little consequence and, in any case, difficult to detect. Macroscopic trauma, however, may lead to significant morbidity. It may occur at a number of sites and be caused by a number of mechanisms (Table 2). The main areas are the lips, teeth, pharyngeal mucosa, tongue, uvula, epiglottis, and the laryngeal apparatus [45]. Trauma may be caused directly by forceful placement or indirectly by compression and can result in laceration and bleeding, ischemic injuries, or neurological injuries as a result of compression of nerves [46], which will be discussed separately.

Table 2.

Sites, types, and mechanisms of traumatic injuries caused by SGAs (modified from Michalek and Donaldson [13]).

Site of injury Type(s) of injury Mechanism(s) of injury
Pharyngeal mucosa Laceration
Bruising
Forceful insertion, inadequate lubrication
Prolonged insertion, too high cuff pressures

Laryngeal apparatus Arytenoid dislocation
Recurrent laryngeal nerve injury
Direct trauma
Compression of the nerve in piriform fossa

Uvula Trauma leading to ischemia and necrosis Direct trauma
Prolonged compression

Epiglottis Bruising
Laceration
Incorrect or forceful insertion, anatomical abnormalities

Tongue Frenular injury
Lingual nerve injury
Incorrect or forceful insertion
Compression of inferior or lateral surface of the tongue by cuff or tube of SGA

Teeth Displacement
Fracture of roots
Direct trauma
Biting on SGA/bite block

Lips Laceration
Nerve injury
Direct trauma
Compression by device, taping to device

2.2.1. Minor Trauma

Dental injuries occur in about 1% of anesthetics and make up a significant proportion of legal claims against practitioners [47]. Dental injuries occur less frequently with SGA insertion than they do with direct laryngoscopy [48], but they may be also associated with removal of these devices.

There is only one publication mentioning dental damage in association with either the cLMA [49] or intubating LMA [50]. Few studies have looked for or mentioned dental damage in association with the i-gel but the incidence was almost zero [5153].

The cLMA has been reported as the victim of trauma in one report: a sharp crown exposed by decay tore the cuff of two devices during insertion [54].

The presence of blood on the device upon removal of a SGA often indicates minor trauma associated with device insertion. The reported incidence of this for the cLMA is between 12 and 15% [55] and 9 and 22% in association with the PLMA [56, 57], depending on insertion technique. An incidence of blood staining of 20% has been described with the Guardian CPV laryngeal mask [57]. The typical incidence of blood on the i-gel at removal is between 4% and 13% [5860] but has been reported to be as high as 20%, albeit in novice users [61]. The AuraOnce laryngeal mask was associated with a very low (2%) incidence of blood staining after its removal [62] but reached 10% in another study [63]. The presence of blood on the Cobra airway may be as high as 50% [64]. Aydogmus et al. reported a 7.5% incidence of blood staining on the LMA Supreme in pediatric patients, which was significantly lower than with the LMA ProSeal [65]. Insertion of the SLIPA may be associated with minor trauma in more than 20% of patients [66, 67]. Insertion of a novel SGA, the Baska mask, has been associated with significantly higher incidence of oropharyngeal trauma than the single-use cLMA, as reported by blood staining observed on the device after removal. However, this fact was not associated with an increased incidence of laryngospasm or postoperative complaints [68]. Five different 2nd-generation SGAs were inserted by inexperienced operators in another study [69]. SLMA, PLMA, i-gel, and LTS-D showed lower incidence of blood staining on removal than SLIPA. However, their patients were not surveyed postoperatively for symptoms of pharyngolaryngeal morbidity.

Theiler et al. analyzed complications associated with the use of i-gel in 2049 patients. They experienced 1.2% incidence of laryngospasm, 3.9% incidence of blood staining on the device, 2 cases of transient nerve damage, and one case of glottic hematoma after uncomplicated device insertion [70].

Injury to the lingual frenulum during insertion has been reported with use of the LMA ProSeal [71, 72] and the i-gel [73]. The mechanism of injury is usually backward folding of the tongue on insertion [74], thus stretching the lingual frenulum.

Trauma to the uvula or uvulitis has been described following insertion of laryngeal mask airway [75].

Ischemia of the tongue has been described in association with the intubating LMA after prolonged insertion [76] and also with the cLMA—again after a period of prolonged insertion [77]. A vacuum-like effect has been suggested to cause a hematoma on the lateral edge of the tongue following insertion of the 3gLM airway [78].

Pharyngeal lacerations have also been reported in association with the cLMA and in one case this led to the pulmonary aspiration of blood [79]. A different site of injury (aryepiglottic fold) led to massive hemorrhage after withdrawal of an i-gel [80].

Arytenoid dislocation has been reported after airway maintenance with a cLMA [81] which could be caused by direct contact with arytenoids, insertion with inflated cuff, or device rotation during placement. Despite strictly recommended methods of insertion, both uvular [82, 83] and epiglottic injuries [84] have been associated with use of the laryngeal mask. Arytenoid cartilage dislocation, as well as recurrent laryngeal nerve trauma with subsequent unilateral vocal cord palsy, has been described in association with the SLIPA [85]. Both complications led to persistent hoarseness.

2.2.2. Major Trauma

Severe damage to the pharyngeal structures or esophagus leading to life-threatening complications is extremely rare with SGAs. However, a few cases have been described in the literature. Blind insertion of a tracheal tube through the intubating laryngeal mask airway (ILMA) probably caused perforation of the esophageal diverticulum in an elderly patient which led to development of a pneumomediastinum [86]. The patient died nine weeks later due to multiorgan failure. Deep neck abscess and mediastinitis following pharyngeal perforation caused by cLMA insertion have been described in a low-risk elective procedure [87]. A similar complication causing a prolonged ICU and hospital stay was described following traumatic cLMA insertion for an elective urology procedure [88]. Both patients survived but required thoracic surgery intervention and prolonged mechanical ventilation. A posterolateral lesion of the pharyngeal wall after an uncomplicated insertion of cLMA was described in another elective patient [89]. Subsequent subcutaneous emphysema, pneumomediastinum, and pneumoperitoneum resolved spontaneously after several days. A recent report presented serious oropharyngeal trauma associated with the use of i-gel [90]. An elderly patient with multiple osteophytes on the cervical spine developed an airway obstruction few weeks after the procedure. Extensive hypopharyngeal mucosal erosions with denudation of the cricoid cartilage and subsequent supraglottic edema resulted in emergency tracheotomy and prolonged artificial ventilation. The authors suggested that age, duration of surgery, and pathology of the cervical spine contributed to this trauma.

2.3. Nerve Injuries

Innervation of the structures which SGAs come into contact with is complex. There are risks associated with device insertion and fixation and with the device in situ. Lesions to the lingual nerve have been repeatedly described with use of the cLMA [9193], the PLMA [94], SLMA [95, 96], and i-gel [95, 97]. Injuries to the hypoglossal nerve have been described in association with using the cLMA [98, 99], PLMA [100], and SLMA [101]. Injuries to the recurrent laryngeal nerve have been described in association with the cLMA in adults [102105] or children [106] and with insertion of the SLIPA [85].

Whilst the etiology of neurological injury by SGAs is multifactorial, in many of these cases the inflatable cuff of the devices was implicated—either by causing the device to be too rigid during insertion or by direct compression of nervous structures whilst the device was in place.

Despite its lack of a cuff, nerve injury in association with the i-gel has been described; Theron described a case of likely mental nerve injury [107]. In a reply to this letter, Chapman stresses the importance of taping the device correctly and of correct size selection, lubrication, and insertion technique [108].

Renes presented a case of bilateral lingual nerve injury in association with the use of an i-gel [97]. Another letter also refers to symptoms, which are consistent with an injury to the lingual nerve [73].

In their cohort study, Theiler et al. reported two instances of neurological damage [70]. The authors emphasise that device selection should involve choosing the smallest device that provides an adequate airway seal—particularly in those patients who are overweight or who are anesthetized for longer procedures.

2.4. Minor Complications

These mainly include sore throat, swallowing difficulties, and hoarseness lasting for up to several days after anesthesia. The etiology of postoperative sore throat (POST) is unclear. Factors associated with its increased incidence include female sex, use of suxamethonium, younger patients, and patients undergoing gynecological surgery [109]. Trauma to different areas by different devices (SGAs and endotracheal tubes) causes a similar incidence of sore throat postoperatively [110].

The incidence of sore throat associated with use of the cLMA ranges from 5.8% to 34% compared with 14.4% to 53% in association with endotracheal intubation [109]. There are differences in the sites of forces applied by a supraglottic airway (posterior pharynx) and endotracheal tubes (glottic entrance) which explain the different nature of complaints associated with them; dysphonia is more common with an endotracheal tube, and dysphagia more common with SGAs [111]. The incidence of sore throat after the use of other SGAs is not very different—AuraOnce LM up to 22%, the i-gel between 5% and 17% [62, 112]. Kihara et al. do not recommend using ILMA instead of cLMA for routine procedures due to its significantly higher pharyngolaryngeal morbidity including sore throat (34–59%) and swallowing difficulties (up to 31%) [113]. Limited evidence is available to show that those SGAs with a gastric channel (2nd generation) may cause less sore throat and swallowing difficulties than the 1st-generation devices [112]. SLIPA has demonstrated a very low incidence (2%–8.6%) of postoperative sore throat and swallowing difficulties [66, 67]. The incidence of minor postoperative complaints has also been studied in other base-of-tongue sealing devices. The Cobra PLA airway may cause sore throat postoperatively with the incidence rising up to 31% as the cuff volume and pressure are increased [114]. Turan and colleagues found a significantly higher incidence of POST in patients managed with the Cobra PLA airway—50%—compared to those who had the PLMA or Laryngeal Tube inserted [64]. The incidence of sore throat and dysphagia following insertion of the LT or LTS II (LTS-D) has been reported at between 8% and 20% [115, 116]. The LTS-D showed a significantly higher incidence of postoperative sore throat and dysphagia than both the i-gel and SLMA [117].

There are several factors that may lead to the development of a sore throat with SGA use and they are highlighted in Table 3.

Table 3.

Possible factors implicated in the development of postoperative sore throat with SGAs.

Factor Mechanism
Insertion technique Leading edge of deflated cuff may cause trauma
Inflated cuff causes more epiglottic downfolding, which increases POST
Repeated attempts are associated with increased POST

Size of device Smaller sizes of SGAs are associated with less POST

Use of lubricants Adequate lubrication is essential
Lidocaine gel is associated with an increase in POST

Overinflation of the cuff Some studies have shown decreased POST with intracuff pressure monitoring

Duration of surgery Increased POST in operations of over 60 min duration

Airway gases Lack of humidification can dry mucosal surfaces and increase POST

3. Effect of SGAs on Cervical Vascular Structures

Supraglottic airway devices may cause distortion of anatomical structures in the neck. The inflated cuff of laryngeal mask airways lies at the level of the cricoid cartilage and its expansion may change the position and/or diameter of the common carotid artery and internal jugular vein.

The clinical effects of cuff inflation on neck vessels were first studied by Colbert et al. [118]. They initially performed a pilot evaluation of carotid artery diameter and flow in a patient who was scheduled for elective surgery under general anesthesia. The cross-sectional area of both carotid arteries significantly decreased after inflation of the LMA cuff which was compensated for by an increase in flow velocity and carotid blood flow. In their subsequent study, the authors evaluated carotid artery hemodynamics in seventeen patients who had cLMA inserted for routine elective cases under general anesthesia [119]. The cross-sectional area of the carotid arteries significantly differed between cuff inflation and deflation. Carotid blood flow was also significantly lower during cuff inflation whereas no difference was observed in flow velocity. Reduction in the carotid artery diameter was more marked in patients older than 60 years where the cross-sectional area dropped after inflation by more than 60% when compared with the area measured during cuff deflation. The results of this study suggest a potential deleterious effect of the laryngeal mask airway on brain perfusion in older patients, which can be further potentiated by a presence of sclerotic plaques inside the carotid arteries.

The significance of these findings in patients with normal perfusion parameters remains debatable. Compression of neck vessels may have deleterious effects on brain perfusion in patients with low-flow conditions, such as resuscitation in cardiac arrest or hypovolemia. Segal et al. studied the relationship between three SGAs (King Laryngeal Tube Suction-D, Laryngeal Mask Airway Flexible, and Combitube 41F) and carotid artery blood flow in an experimental swine model of cardiac arrest [120]. The authors found that insertion and cuff inflation of each of the three SGAs caused a significant reduction in carotid blood flow as compared with the control group, which was managed with tracheal intubation. Postmortem arteriograms were performed for each airway device and showed that all three SGAs were associated with a compression of the common, internal, and external carotid arteries.

Laryngeal mask insertion may change the anatomical relationship of the common carotid artery and internal jugular vein [121]. This changed in 8.3% of children following inflation of the laryngeal mask cuff [122]. Intracuff pressures of the LMA should be measured regularly during general anesthesia because an overinflated cuff may cause congestion of the neck veins [123].

There is no evidence available regarding the effect of other or newer SGAs such as the SLMA, i-gel, SLIPA, Cobra PLA, or Laryngeal Tubes on carotid cross-sectional area or carotid blood flow.

4. Pressures Exerted by SGAs on Pharyngeal Mucosa

Tracheal tubes may cause damage to the tracheal mucosa which can manifest itself as postintubation edema, narrowing or, in prolonged intubation, as tracheal stenosis [124]. The inflated cuff of the tracheal tube may also damage the recurrent laryngeal nerves, more commonly in children [125]. Supraglottic airway devices do not have any effect on the tracheal mucosa. Marjot raised the first concerns about a negative effect of SGAs on oropharyngeal mucosa in 1993 [126]. He measured the intracuff pressures inside the bowl of the cLMA in ten patients under general anesthesia and found them to range between 103 and 251 mmHg. He suggested that transmitted mucosal pressures might potentially exceed capillary perfusion pressure in the hypopharynx. Similar concerns were also raised by O'Kelly and colleagues [127].

Subsequent studies were performed by Keller and Brimacombe's group. These researchers put microchip sensors on the outer surface of various SGAs and measured the pressures exerted by these devices on various parts of pharyngeal and perilaryngeal areas. The findings of their initial studies suggested that the actual pressures are probably much lower than those calculated and do not exceed the capillary perfusion pressures [128].

The same authors showed, on a cadaver model, that pressures exerted by the tracheoesophageal Combitube on pharyngeal and esophageal mucosa are quite high and that they may exceed mucosal perfusion pressures [129]. Another type of base-of-tongue sealer, the Laryngeal Tube, also showed a potential for pressure trauma to pharyngeal structures [130]. Extended insertion of supraglottic airway devices may significantly contribute to the pharyngeal mucosa hypoperfusion. LMA ProSeal inserted over a period of 12 hours was associated with a significantly increased incidence of mucosal injury in an animal model when compared with shorter periods of time [131]. Nitrous oxide, which is still used by some anesthesiologists, diffuses into the cuff of any inflatable SGA, expanding its size and increasing the intracuff pressures [132]. However, these higher pressures caused only mild histological signs of pharyngeal mucosal injury in an animal model for procedures of up to 2 h of duration [132, 133].

Human studies have been carried out for most currently used SGAs. The cLMA was compared with the intubating LMA in anesthetized and paralyzed adults. The intubating LMA was associated with significantly higher seal pressures but pressures exerted on the mucosa in the distal oropharynx were more than 157 cm H2O, exceeding mucosal perfusion pressures in that area [134]. Pressures exerted on the pharyngeal mucosa with the intubating LMA were even higher than in devices employing base-of-tongue or pharyngeal sealing as their primary mechanism (Laryngeal Tube, Easy Tube, or Combitube) [135]. The i-gel airway and LMA Supreme were compared in regard to pressures exerted onto the oropharyngeal and perilaryngeal mucosal tissue [59]. Both devices exhibited very low pressures (not exceeding 10 cmH2O). The i-gel did not show any pressure differences but pressures exerted by LMA Supreme were lower at the base of the tongue and distal oropharynx than in the hypopharynx. No data about their effect on mucosa are available for the SLIPA, Cobra airway, or novel devices such as the Baska mask, AuraGain LM, Guardian LM, or 3gLM.

Two studies confirmed an increase in the cuff volume, intracuff pressures, and transmitted mucosal pressures, depending on the increasing altitude, in tracheal tubes and SGAs when cuffs were filled with air [136, 137]. These findings raised concerns as whether to fill these cuffs with saline, to check the intracuff pressures at regular intervals, or to use SGAs with a noninflatable cuff such as the i-gel [138].

5. Conclusions

In many indications, such as for elective procedures outside of the thorax and abdomen in patients without increased risk for gastric content aspiration, SGAs have already replaced tracheal intubation. These devices are still developing in order to overcome their limitations and to minimize the incidence of complications or minor adverse events associated with their insertion.

Complications associated with the correct use of the SGAs are relatively rare and most of them are not life-threatening. They are often associated with a deviation from the manufacturers' advice on usage of their devices. Aspiration remains a problem, which can have serious and even fatal consequences. Its incidence is extremely low, comparable with the incidence of aspiration in tracheal tube anesthesia [25]; however, its real occurrence may be underreported [9]. Although there is some limited evidence that newer devices with an additional gastric channel may offer greater protection from regurgitation and aspiration this still requires robust studies to be carried out. Assessment of the risk of aspiration is a key component of the preanesthetic evaluation and should be used to guide device selection.

Nerve injuries may be avoided by careful insertion and by limiting cuff inflation pressure in accordance with advice from the manufacturer. Limiting cuff pressures may also decrease the incidence of sore throat.

The effects of SGAs on cervical vascular structures and microcirculation of the pharyngeal mucosa are not yet completely explored. It appears that negative effects are directly related to cuff volume and its internal pressure.

Acknowledgment

This work was supported by the institutional support from the 1st Medical Faculty, Charles University in Prague.

Abbreviations

BMI:

Body mass index

ILMA:

Intubating laryngeal mask airway

LM:

Laryngeal mask

LMA:

Laryngeal mask airway

LTS:

Laryngeal Tube Suction

NAP:

National Audit Project

PLA:

Perilaryngeal airway

POST:

Postoperative sore throat

SGA:

Supraglottic airway device

SLIPA:

Streamlined liner of the pharyngeal airway.

Disclosure

Pavel Michalek has lectured for several companies manufacturing supraglottic airway devices including Intersurgical Ltd., AMBU Ltd., and Intavent Orthofix Ltd. William Donaldson has delivered lectures on the i-gel for Intersurgical Ltd.

Conflict of Interests

Eliska Vobrubova and Marek Hakl declare no conflict of interests regarding the publication of this paper.

Authors' Contribution

Pavel Michalek and Eliska Vobrubova performed the literature search, Pavel Michalek and William Donaldson designed the paper, Marek Hakl created the tables and revised the paper, and Pavel Michalek and William Donaldson prepared final version of the paper. All authors have approved the final version of the paper.

References

  • 1.Hernandez M. R., Klock P. A., Jr., Ovassapian A. Evolution of extraglottic airway: a review of its history, applications, and practical tips for success. Anesthesia and Analgesia. 2012;114(2):349–368. doi: 10.1213/ane.0b013e31823b6748. [DOI] [PubMed] [Google Scholar]
  • 2.Miller D. M. A proposed classification and scoring system for supraglottic sealing airways: a brief review. Anesthesia and Analgesia. 2004;99(5):1553–1559. doi: 10.1213/01.ane.0000134798.00069.2b. [DOI] [PubMed] [Google Scholar]
  • 3.Michálek P., Miller D. M. Airway management evolution—in a search for an ideal extraglottic airway device. Prague Medical Report. 2014;115(3-4):87–103. doi: 10.14712/23362936.2014.40. [DOI] [PubMed] [Google Scholar]
  • 4.Leech B. C. The pharyngeal bulb gasway: a new aid in cyclopropane anesthesia. Current Researches in Anesthesia & Analgesia. 1937;16(1):22–25. doi: 10.1213/00000539-193701000-00008. [DOI] [Google Scholar]
  • 5.Brain A. I. J. The laryngeal mask—a new concept in airway management. British Journal of Anaesthesia. 1983;55(8):801–805. doi: 10.1093/bja/55.8.801. [DOI] [PubMed] [Google Scholar]
  • 6.Wong D. T., Yang J. J., Mak H. Y., Jagannathan N. Use of intubation introducers through a supraglottic airway to facilitate tracheal intubation: a brief review. Canadian Journal of Anesthesia. 2012;59(7):704–715. doi: 10.1007/s12630-012-9714-8. [DOI] [PubMed] [Google Scholar]
  • 7.Henlin T., Michalek P., Tyll T., Hinds J. D., Dobias M. Oxygenation, ventilation, and airway management in out-of-hospital cardiac arrest: a review. BioMed Research International. 2014;2014:11. doi: 10.1155/2014/376871.376871 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Woodall N. M., Cook T. M. National census of airway management techniques used for anaesthesia in the UK: first phase of the Fourth National Audit Project at the Royal College of Anaesthetists. British Journal of Anaesthesia. 2011;106(2):266–271. doi: 10.1093/bja/aeq339. [DOI] [PubMed] [Google Scholar]
  • 9.Cook T. M., Woodall N., Frerk C., Fourth National Audit Project Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 1: anaesthesia. British Journal of Anaesthesia. 2011;106(5):617–631. doi: 10.1093/bja/aer058. [DOI] [PubMed] [Google Scholar]
  • 10.Cheon G., Siddiqui S., Lim T., et al. Thinking twice before using the LMA for obese and older patients—a prospective observational study. Journal of Anesthesia and Clinical Research. 2013;4(2, article 283) doi: 10.4172/2155-6148.1000283. [DOI] [Google Scholar]
  • 11.Ferson D. Z., Rosenblatt W. H., Johansen M. J., Osborn I., Ovassapian A. Use of the intubating lma-fastrach in 254 patients with difficult-to-manage airways. Anesthesiology. 2001;95(5):1175–1181. doi: 10.1097/00000542-200111000-00022. [DOI] [PubMed] [Google Scholar]
  • 12.Liu E. H., Wender R., Goldman A. J. The LMA CTrach in patients with difficult airways. Anesthesiology. 2009;110(4):941–943. doi: 10.1097/aln.0b013e31819b62c7. [DOI] [PubMed] [Google Scholar]
  • 13.Michalek P., Donaldson W. The I-Gel Supraglottic Airway. New York, NY, USA: Nova Biomedical; 2013. [Google Scholar]
  • 14.Asai T. Editorial II: who is at increased risk of pulmonary aspiration? British Journal of Anaesthesia. 2004;93(4):497–500. doi: 10.1093/bja/aeh234. [DOI] [PubMed] [Google Scholar]
  • 15.Kluger M. T., Short T. G. Aspiration during anaesthesia: a review of 133 cases from the Australian Anaesthetic Incident Monitoring Study (AIMS) Anaesthesia. 1999;54(1):19–26. doi: 10.1046/j.1365-2044.1999.00642.x. [DOI] [PubMed] [Google Scholar]
  • 16.Caplan R. A., Posner K. L., Ward R. J., Cheney F. W. Adverse respiratory events in anesthesia: a closed claims analysis. Anesthesiology. 1990;72(5):828–833. doi: 10.1097/00000542-199005000-00010. [DOI] [PubMed] [Google Scholar]
  • 17.Cook T. M., Macdougall-Davis S. R. Complications and failure of airway management. British Journal of Anaesthesia. 2012;109(1):i68–i85. doi: 10.1093/bja/aes393. [DOI] [PubMed] [Google Scholar]
  • 18.Brodrick P. M., Webster N. R., Nunn J. F. The laryngeal mask airway. A study of 100 patients during spontaneous breathing. Anaesthesia. 1989;44(3):238–241. doi: 10.1111/j.1365-2044.1989.tb11233.x. [DOI] [PubMed] [Google Scholar]
  • 19.Griffin R. M., Hatcher I. S. Aspiration pneumonia and the laryngeal mask airway. Anaesthesia. 1990;45(12):1039–1040. doi: 10.1111/j.1365-2044.1990.tb14882.x. [DOI] [PubMed] [Google Scholar]
  • 20.Nanji G. M., Maltby J. R. Vomiting and aspiration pneumonitis with the laryngeal mask airway. Canadian Journal of Anaesthesia. 1992;39(1):69–70. doi: 10.1007/bf03008676. [DOI] [PubMed] [Google Scholar]
  • 21.Brain A. I. J. Regurgitation and the laryngeal mask. Canadian Journal of Anaesthesia. 1992;39(7):743–744. doi: 10.1007/bf03008241. [DOI] [PubMed] [Google Scholar]
  • 22.Brimacombe J. R., Berry A. The incidence of aspiration associated with the laryngeal mask airway: a meta-analysis of published literature. Journal of Clinical Anesthesia. 1995;7(4):297–305. doi: 10.1016/0952-8180(95)00026-e. [DOI] [PubMed] [Google Scholar]
  • 23.Verghese C., Brimacombe J. R. Survey of laryngeal mask airway usage in 11,910 patients: safety and efficacy for conventional and nonconventional usage. Anesthesia and Analgesia. 1996;82(1):129–133. doi: 10.1097/00000539-199601000-00023. [DOI] [PubMed] [Google Scholar]
  • 24.Bernardini A., Natalini G. Risk of pulmonary aspiration with laryngeal mask airway and tracheal tube: analysis on 65 712 procedures with positive pressure ventilation. Anaesthesia. 2009;64(12):1289–1294. doi: 10.1111/j.1365-2044.2009.06140.x. [DOI] [PubMed] [Google Scholar]
  • 25.Warner M. A., Warner M. E., Weber J. G. Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology. 1993;78(1):56–62. doi: 10.1097/00000542-199301000-00010. [DOI] [PubMed] [Google Scholar]
  • 26.Robinson M., Davidson A. Aspiration under anaesthesia: risk assessment and decision-making. Continuing Education in Anaesthesia, Critical Care & Pain. 2014;14(4):171–175. doi: 10.1093/bjaceaccp/mkt053. [DOI] [Google Scholar]
  • 27.Keller C., Brimacombe J., Bittersohl J., Lirk P., von Goedecke A. Aspiration and the laryngeal mask airway: three cases and a review of the literature. British Journal of Anaesthesia. 2004;93(4):579–582. doi: 10.1093/bja/aeh228. [DOI] [PubMed] [Google Scholar]
  • 28.Cook C., Gande A. R. Aspiration and death associated with the use of the laryngeal mask airway. British Journal of Anaesthesia. 2005;95(3):425–426. doi: 10.1093/bja/aei581. [DOI] [PubMed] [Google Scholar]
  • 29.Miller D. M., Light D. Storage capacities of the laryngeal mask and laryngeal tube compared and their relevance to aspiration risk during positive pressure ventilation. Anesthesia and Analgesia. 2003;96(6):1821–1822. doi: 10.1213/01.ANE.0000066016.91632.25. [DOI] [PubMed] [Google Scholar]
  • 30.Cook T. M., Lowe J. M. An evaluation of the Cobra Perilaryngeal Airway: study halted after two cases of pulmonary aspiration. Anaesthesia. 2005;60(8):791–796. doi: 10.1111/j.1365-2044.2005.04261.x. [DOI] [PubMed] [Google Scholar]
  • 31.de Silva K. K., Young P. Protection against aspiration with the Proseal laryngeal mask airway. Anaesthesia and Intensive Care. 2002;30(3):p. 391. [PubMed] [Google Scholar]
  • 32.Koay C. K. A case of aspiration using the ProSeal LMA. Anaesthesia and Intensive Care. 2003;31(1):p. 123. [PubMed] [Google Scholar]
  • 33.Brimacombe J., Keller C. Aspiration of gastric contents during use of a ProSeal laryngeal mask airway secondary to unidentified foldover malposition. Anesthesia and Analgesia. 2003;97(4):1192–1194. doi: 10.1213/01.ANE.0000078818.64971.44. [DOI] [PubMed] [Google Scholar]
  • 34.Kim Y.-H. Pulmonary aspiration associated with supraglottic airways: proseal laryngeal mask airway and I-Gel. Korean Journal of Anesthesiology. 2012;63(6):489–490. doi: 10.4097/kjae.2012.63.6.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Taneja S., Agarwal M., Dali J. S., Agrawal G. Ease of Proseal Laryngeal Mask Airway insertion and its fibreoptic view after placement using gum elastic bougie: a comparison with conventional techniques. Anaesthesia and Intensive Care. 2009;37(3):435–440. doi: 10.1177/0310057X0903700306. [DOI] [PubMed] [Google Scholar]
  • 36.Martínez-Pons V., Madrid V. Ease placement of LMA proseal with a gastric tube inserted. Anesthesia and Analgesia. 2004;98(6):1816–1817. doi: 10.1213/01.ANE.0000120096.49638.FF. [DOI] [PubMed] [Google Scholar]
  • 37.Perilli V., Aceto P., Sacco T., Martella N., Cazzato M. T., Sollazzi L. Suction catheter guided insertion of ProSeal laryngeal mask airway: experience by untrained physicians. Indian Journal of Anaesthesia. 2014;58(1):25–29. doi: 10.4103/0019-5049.126784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38.Nagata T., Kishi Y., Tanigami H., et al. Oral gastric tube-guided insertion of the ProSeal laryngeal mask is an easy and noninvasive method for less experienced users. Journal of Anesthesia. 2012;26(4):531–535. doi: 10.1007/s00540-012-1361-2. [DOI] [PubMed] [Google Scholar]
  • 39.Maitra S., Khanna P., Baidya D. K. Comparison of laryngeal mask airway Supreme and laryngeal mask airway Pro-Seal for controlled ventilation during general anaesthesia in adult patients: systematic review with meta-analysis. European Journal of Anaesthesiology. 2014;31(5):266–273. doi: 10.1097/01.eja.0000435015.89651.3d. [DOI] [PubMed] [Google Scholar]
  • 40.Yao W. Y., Li S. Y., Sng B. L., Lim Y., Sia A. T. H. The LMA Supreme in 700 parturients undergoing Cesarean delivery: an observational study. Canadian Journal of Anesthesia. 2012;59(7):648–654. doi: 10.1007/s12630-012-9718-4. [DOI] [PubMed] [Google Scholar]
  • 41.Gibbison B., Cook T. M., Seller C. Case series: protection from aspiration and failure of protection from aspiration with the i-gel airway. British Journal of Anaesthesia. 2008;31(100):415–417. doi: 10.1093/bja/aem396. [DOI] [PubMed] [Google Scholar]
  • 42.Liew G., John B., Ahmed S. Aspiration recognition with an i-gel airway. Anaesthesia. 2008;63(7):p. 786. doi: 10.1111/j.1365-2044.2008.05597.x. [DOI] [PubMed] [Google Scholar]
  • 43.Schmidbauer W., Bercker S., Volk T., Bogusch G., Mager G., Kerner T. Oesophageal seal of the novel supralaryngeal airway device I-Gel in comparison with the laryngeal mask airways Classic and ProSeal using a cadaver model. British Journal of Anaesthesia. 2009;102(1):135–139. doi: 10.1093/bja/aen319. [DOI] [PubMed] [Google Scholar]
  • 44.Cook T. M., Kelly F. E. Time to abandon the ‘vintage’ laryngeal mask airway and adopt second-generation supraglottic airway devices as first choice. British Journal of Anaesthesia. 2015;115(4):497–499. doi: 10.1093/bja/aev156. [DOI] [PubMed] [Google Scholar]
  • 45.Pacheco-Lopez P. C., Berkow L. C., Hillel A. T., Akst L. M. Complications of airway management. Respiratory Care. 2014;59(6):1006–1021. doi: 10.4187/respcare.02884. [DOI] [PubMed] [Google Scholar]
  • 46.Thiruvenkatarajan V., van Wijk R. M., Rajbhoj A. Cranial nerve injuries with supraglottic airway devices: a systematic review of published case reports and series. Anaesthesia. 2015;70(3):344–359. doi: 10.1111/anae.12917. [DOI] [PubMed] [Google Scholar]
  • 47.Cass N. M. Medicolegal claims against anaesthetists: a 20 year study. Anaesthesia and Intensive Care. 2004;32(1):47–58. doi: 10.1177/0310057X0403200108. [DOI] [PubMed] [Google Scholar]
  • 48.Yasny J. S. Perioperative dental considerations for the anesthesiologist. Anesthesia and Analgesia. 2009;108(5):1564–1573. doi: 10.1213/ane.0b013e31819d1db5. [DOI] [PubMed] [Google Scholar]
  • 49.Chau S.-W., Wang F.-Y., Wu C.-W., et al. Premolar loss following insertion of a classic laryngeal mask airway in a patient in the prone position. Journal of Clinical Anesthesia. 2011;23(7):588–589. doi: 10.1016/j.jclinane.2010.08.024. [DOI] [PubMed] [Google Scholar]
  • 50.Asai T. Dental damage caused by the intubating laryngeal mask airway. Anesthesia & Analgesia. 2006;103(3):p. 785. doi: 10.1213/01.ane.0000227159.94345.3a. [DOI] [PubMed] [Google Scholar]
  • 51.Teoh W. H. L., Lee K. M., Suhitharan T., Yahaya Z., Teo M. M., Sia A. T. H. Comparison of the LMA Supreme vs the i-gel in paralysed patients undergoing gynaecological laparoscopic surgery with controlled ventilation. Anaesthesia. 2010;65(12):1173–1179. doi: 10.1111/j.1365-2044.2010.06534.x. [DOI] [PubMed] [Google Scholar]
  • 52.Jindal P., Rizvi A. A., Khurana G., Sharma J. P. Safety an efficacy of insertion of supraglottic devices in anaesthetised patients by first-time users. Southern African Journal of Anaesthesia and Analgesia. 2010;16(4):23–26. doi: 10.1080/22201173.2010.10872694. [DOI] [Google Scholar]
  • 53.Singh I., Gupta M., Tandon M. Comparison of clinical performance of I-Gel with LMA-proseal in elective surgeries. Indian Journal of Anaesthesia. 2009;53(3):302–305. [PMC free article] [PubMed] [Google Scholar]
  • 54.McLure H. A. Dental damage to the laryngeal mask. Anaesthesia. 1996;51(11):1078–1079. doi: 10.1111/j.1365-2044.1996.tb15020.x. [DOI] [PubMed] [Google Scholar]
  • 55.Parker M. R. J., Day C. J. E. Visible and occult blood contamination of laryngeal mask airways and tracheal tubes used in adult anaesthesia. Anaesthesia. 2000;55(4):388–390. doi: 10.1046/j.1365-2044.2000.01281.x. [DOI] [PubMed] [Google Scholar]
  • 56.Hwang J.-W., Park H.-P., Lim Y.-J., Do S.-H., Lee S.-C., Jeon Y.-T. Comparison of two insertion techniques of ProSeal laryngeal mask airway: standard versus 90-degree rotation. Anesthesiology. 2009;110(4):905–907. doi: 10.1097/aln.0b013e31819b5d40. [DOI] [PubMed] [Google Scholar]
  • 57.Pajiyar A. K., Wen Z., Wang H., Ma L., Miao L., Wang G. Comparisons of clinical performance of guardian laryngeal mask with laryngeal mask airway ProSeal. BMC Anesthesiology. 2015;15(1, article 69) doi: 10.1186/s12871-015-0039-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 58.Lee J.-R., Kim M.-S., Kim J.-T., et al. A randomised trial comparing the i-gel with the LMA classic in children. Anaesthesia. 2012;67(6):606–611. doi: 10.1111/j.1365-2044.2012.07072.x. [DOI] [PubMed] [Google Scholar]
  • 59.Eschertzhuber S., Brimacombe J., Kaufmann M., Keller C., Tiefenthaler W. Directly measured mucosal pressures produced by the i-gelTM and laryngeal mask airway Supreme in paralysed anaesthetised patient. Anaesthesia. 2012;67(4):407–410. doi: 10.1111/j.1365-2044.2011.07024.x. [DOI] [PubMed] [Google Scholar]
  • 60.Kleine-Brueggeney M., Theiler L., Urwyler N., Vogt A., Greif R. Randomized trial comparing the i-gel and Magill tracheal tube with the single-use ILMA and ILMA tracheal tube for fibreoptic-guided intubation in anaesthetized patients with a predicted difficult airway. British Journal of Anaesthesia. 2011;107(2):251–257. doi: 10.1093/bja/aer103. [DOI] [PubMed] [Google Scholar]
  • 61.Ragazzi R., Finessi L., Farinelli I., Alvisi R., Volta C. A. LMA Supreme vs i-gel—a comparison of insertion success in novices. Anaesthesia. 2012;67(4):384–388. doi: 10.1111/j.1365-2044.2011.07002.x. [DOI] [PubMed] [Google Scholar]
  • 62.Donaldson W., Abraham A., Deighan M., Michalek P. I-gel vs. AuraOnce laryngeal mask for general anaesthesia with controlled ventilation in paralyzed patients. Biomedical Papers. 2011;155(2):155–163. doi: 10.5507/bp.2011.023. [DOI] [PubMed] [Google Scholar]
  • 63.Williams D. L., Zeng J. M., Alexander K. D., Andrews D. T. Randomised comparison of the AMBU AuraOnce laryngeal mask and the LMA unique laryngeal mask airway in spontaneously breathing adults. Anesthesiology Research and Practice. 2012;2012:5. doi: 10.1155/2012/405812.405812 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 64.Turan A., Kaya G., Koyuncu O., Karamanlioglu B., Pamukçu Z. Comparison of the laryngeal mask (LMA) and laryngeal tube (LT) with the new perilaryngeal airway (CobraPLA) in short surgical procedures. European Journal of Anaesthesiology. 2006;23(3):234–238. doi: 10.1017/s0265021505002243. [DOI] [PubMed] [Google Scholar]
  • 65.Aydogmus M. T., Eksioglu B., Oba S., et al. Comparison of laryngeal mask airway Supreme and laryngeal mask airway ProSeal for laryngopharyngeal trauma and postoperative morbidity in children. Revista Brasileira de Anestesiologia. 2013;63(6):445–449. doi: 10.1016/j.bjane.2012.08.004. [DOI] [PubMed] [Google Scholar]
  • 66.Abdellatif A. A., Ali M. A. Comparison of streamlined liner of the pharynx airway (SLIPA) with the laryngeal mask airway Proseal for lower abdominal laparoscopic surgeries in paralyzed, anesthetized patients. Saudi Journal of Anaesthesia. 2011;5(3):270–276. doi: 10.4103/1658-354x.84100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 67.Lange M., Smul T., Zimmermann P., Kohlenberger R., Roewer N., Kehl F. The effectiveness and patient comfort of the novel streamlined pharynx airway liner (SLIPA) compared with the conventional laryngeal mask airway in ophthalmic surgery. Anesthesia and Analgesia. 2007;104(2):431–434. doi: 10.1213/01.ane.0000252460.94046.7c. [DOI] [PubMed] [Google Scholar]
  • 68.Alexiev V., Ochana A., Abdelrahman D., et al. Comparison of the Baska mask with the single-use laryngeal mask airway in low-risk female patients undergoing ambulatory surgery. Anaesthesia. 2013;68(10):1026–1032. doi: 10.1111/anae.12356. [DOI] [PubMed] [Google Scholar]
  • 69.Henlin T., Sotak M., Kovaricek P., Tyll T., Balcarek L., Michalek P. Comparison of five 2nd-generation supraglottic airway devices for airway management performed by novice military operators. BioMed Research International. 2015;2015:8. doi: 10.1155/2015/201898.201898 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 70.Theiler L., Gutzmann M., Kleine-Brueggeney M., Urwyler N., Kaempfen B., Greif R. I-gel supraglottic airway in clinical practice: a prospective observational multicentre study. British Journal of Anaesthesia. 2012;109(6):990–995. doi: 10.1093/bja/aes309. [DOI] [PubMed] [Google Scholar]
  • 71.Haris Z. M., Loo W. T., Brimacombe J. Frenular injury during insertion of the ProSeal laryngeal mask airway using the introducer tool technique. Anesthesia and Analgesia. 2006;102(6):1906–1907. doi: 10.1213/01.ane.0000215118.19677.3f. [DOI] [PubMed] [Google Scholar]
  • 72.Park M. J., Kim H. S., Kim J. T., Kim C. S., Kim S. D. Tearing of the lingual frenulum caused by insertion of the ProSeal LMA in a child: a case report. Korean Journal of Anesthesiology. 2009;57(5):p. 644. doi: 10.4097/kjae.2009.57.5.644. [DOI] [PubMed] [Google Scholar]
  • 73.Michalek P., Donaldson W. J., Hinds J. D. Tongue trauma associated with the i-gel supraglottic airway. Anaesthesia. 2009;64(6):p. 692. doi: 10.1111/j.1365-2044.2009.05954_1.x. [DOI] [PubMed] [Google Scholar]
  • 74.Taxak S., Gopinath A. Insertion of the i-gel airway obstructed by the tongue. Anesthesiology. 2010;112(2):500–501. doi: 10.1097/aln.0b013e3181c98f10. [DOI] [PubMed] [Google Scholar]
  • 75.Ziahosseini K., Ali S., Simo R., Malhotra R. Uvulitis following general anaesthesia. BMJ Case Reports. 2014;2014 doi: 10.1136/bcr-2014-205038.A1841 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 76.Gerstein N. S., Braude D., Harding J. S., Douglas A. Lingual ischemia from prolonged insertion of a Fastrach laryngeal mask airway. Western Journal of Emergency Medicine. 2011;12(1):124–127. [PMC free article] [PubMed] [Google Scholar]
  • 77.Britz G., Nimjee S., Wright D., Agrawal A., McDonagh D., Husain A. Tongue swelling and necrosis after brain tumor surgery. Asian Journal of Neurosurgery. 2012;7(4):214–216. doi: 10.4103/1793-5482.106658. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 78.Michalek P., Jindrova B., Kriz P., Stritesky M., Sedlar M. A pilot evaluation of the 3gLM-R—a new supraglottic airway device. Advances in Medical Sciences. 2015;60(2):186–190. doi: 10.1016/j.advms.2015.02.001. [DOI] [PubMed] [Google Scholar]
  • 79.Norton A., Germonpré J., Semple T. Pulmonary aspiration of blood following traumatic laryngeal mask airway insertion. Anaesthesia and Intensive Care. 1998;26(2):213–215. doi: 10.1177/0310057X9802600217. [DOI] [PubMed] [Google Scholar]
  • 80.Dangelser G., Dincq A. S., Lawson G., Collard E. Case report: severe laryngeal hemorrhage after withdrawal of a size 5 I-gel in elective surgery. Acta Anaesthesiologica Belgica. 2009;60(4):255–257. [PubMed] [Google Scholar]
  • 81.Rosenberg M. K., Rontal E., Rontal M., Lebenbom-Mansour M. Arytenoid cartilage dislocation caused by a laryngeal mask airway treated with chemical splinting. Anesthesia and Analgesia. 1996;83(6):1335–1336. doi: 10.1097/00000539-199612000-00037. [DOI] [PubMed] [Google Scholar]
  • 82.Lee J. J. Laryngeal mask and trauma to uvula. Anaesthesia. 1989;44(12):p. 1014. doi: 10.1111/j.1365-2044.1989.tb09242.x. [DOI] [PubMed] [Google Scholar]
  • 83.Emmett S. R., Lloyd S. D., Johnston M. N. Uvular trauma from a laryngeal mask. British Journal of Anaesthesia. 2012;109(3):468–469. doi: 10.1093/bja/aes294. [DOI] [PubMed] [Google Scholar]
  • 84.McKinney B., Grigg R. Epiglottitis after anaesthesia with a laryngeal mask. Anaesthesia and Intensive Care. 1995;23(5):618–619. doi: 10.1177/0310057X9502300518. [DOI] [PubMed] [Google Scholar]
  • 85.Ma X.-X., Fang X.-M. Severe hoarseness associated with the streamlined liner of the pharyngeal airway (SLIPATM) Acta Anaesthesiologica Scandinavica. 2015;59(4):531–535. doi: 10.1111/aas.12470. [DOI] [PubMed] [Google Scholar]
  • 86.Branthwaite M. A. An unexpected complication of the intubating laryngeal mask. Anaesthesia. 1999;54(2):166–167. doi: 10.1046/j.1365-2044.1999.00635.x. [DOI] [PubMed] [Google Scholar]
  • 87.Paciuc M. Deep neck abscess and mediastinitis after laryngeal mask anesthesia. Anesthesia and Analgesia. 2009;108(4):1356–1357. doi: 10.1213/ane.0b013e31819543d8. [DOI] [PubMed] [Google Scholar]
  • 88.Yegappan C., Redmond E., Le Dez K. Anterior mediastinitis following traumatic laryngeal mask placement. Canadian Journal of Anaesthesia. 2007;54(supplement 1):p. 44568. doi: 10.1007/bf03019996. [DOI] [Google Scholar]
  • 89.Atalay Y. O., Kaya C., Aktas S., Toker K. A complication of the laryngeal mask airway: pharyngolaryngeal rupture and pneumomediastinum. European Journal of Anaesthesiology. 2015;32(6):439–440. doi: 10.1097/eja.0000000000000195. [DOI] [PubMed] [Google Scholar]
  • 90.Schaer A. C., Keel M. J., Dubach P., Greif R., Luyet C., Theiler L. Mucosal erosion of the cricoid cartilage after the use of an i-gel supraglottic airway device in a patient with diffuse idiopathic skeletal hyperostosis. A & A Case Reports. 2014;3(4):45–47. doi: 10.1213/XAA.0000000000000049. [DOI] [PubMed] [Google Scholar]
  • 91.Majumder S., Hopkins P. M. Bilateral lingual nerve injury following the use of the laryngeal mask airway. Anaesthesia. 1998;53(2):184–186. doi: 10.1046/j.1365-2044.1998.00313.x. [DOI] [PubMed] [Google Scholar]
  • 92.Foley E., Mc Dermott T. E. D., Shanahan E., Phelan D. Transient isolated lingual nerve neuropraxia associated with general anaesthesia and laryngeal mask use: two case reports and a review of the literature. Irish Journal of Medical Science. 2010;179(2):297–300. doi: 10.1007/s11845-009-0347-z. [DOI] [PubMed] [Google Scholar]
  • 93.El Toukhy M., Tweedie O. Bilateral lingual nerve injury associated with classic laryngeal mask airway: a case report. European Journal of Anaesthesiology. 2012;29(8):400–401. doi: 10.1097/eja.0b013e3283514e81. [DOI] [PubMed] [Google Scholar]
  • 94.Brimacombe J., Clarke G., Keller C. Lingual nerve injury associated with the ProSeal laryngeal mask airway: a case report and review of the literature. British Journal of Anaesthesia. 2005;95(3):420–423. doi: 10.1093/bja/aei187. [DOI] [PubMed] [Google Scholar]
  • 95.Rujirojindakul P., Prechawai C., Watanayomnaporn E. Tongue numbness following laryngeal mask airway Supreme and i-gel insertion: two case reports. Acta Anaesthesiologica Scandinavica. 2012;56(9):1200–1203. doi: 10.1111/j.1399-6576.2012.02695.x. [DOI] [PubMed] [Google Scholar]
  • 96.Thiruvenkatarajan V., Van Wijk R. M. A. W., Elhalawani I., Barnes A.-M. Lingual nerve neuropraxia following use of the Laryngeal Mask Airway Supreme. Journal of Clinical Anesthesia. 2014;26(1):65–68. doi: 10.1016/j.jclinane.2013.10.003. [DOI] [PubMed] [Google Scholar]
  • 97.Renes S. H., Zwart R., Scheffer G. J., Renes S. Lingual nerve injury following the use of an i-gel laryngeal mask. Anaesthesia. 2011;66(3):226–227. doi: 10.1111/j.1365-2044.2011.06636.x. [DOI] [PubMed] [Google Scholar]
  • 98.Nagai K., Sakuramoto C., Goto F. Unilateral hypoglossal nerve paralysis following the use of the laryngeal mask airway. Anaesthesia. 1994;49(7):603–604. doi: 10.1111/j.1365-2044.1994.tb14230.x. [DOI] [PubMed] [Google Scholar]
  • 99.Stewart A., Lindsay W. A. Bilateral hypoglossal nerve injury following the use of the laryngeal mask airway. Anaesthesia. 2002;57(3):264–265. doi: 10.1046/j.1365-2044.2002.02231.x. [DOI] [PubMed] [Google Scholar]
  • 100.Trümpelmann P., Cook T. Unilateral hypoglossal nerve injury following the use of a ProSeal laryngeal mask. Anaesthesia. 2005;60(1):101–102. doi: 10.1111/j.1365-2044.2004.04056.x. [DOI] [PubMed] [Google Scholar]
  • 101.Takahoko K., Iwasaki H., Sasakawa T., Suzuki A., Matsumoto H., Iwasaki H. Unilateral hypoglossal nerve palsy after use of the laryngeal mask airway Supreme. Case Reports in Anesthesiology. 2014;2014:4. doi: 10.1155/2014/369563.369563 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 102.Inomata S., Nishikawa T., Suga A., Yamashita S. Transient bilateral vocal cord paralysis after insertion of a laryngeal mask airway. Anesthesiology. 1995;82(3):787–788. doi: 10.1097/00000542-199503000-00023. [DOI] [PubMed] [Google Scholar]
  • 103.Lloyd Jones F. R., Hegab A. Recurrent laryngeal nerve palsy after laryngeal mask airway insertion. Anaesthesia. 1996;51(2):171–172. doi: 10.1111/j.1365-2044.1996.tb07707.x. [DOI] [PubMed] [Google Scholar]
  • 104.Daya H., Fawcett W. J., Weir N. Vocal fold palsy after use of the laryngeal mask airway. Journal of Laryngology and Otology. 1996;110(4):383–384. doi: 10.1017/s0022215100133699. [DOI] [PubMed] [Google Scholar]
  • 105.Cros A. M., Pitti R., Conil C., Giraud D., Verhulst J. Severe dysphonia after use of a laryngeal mask airway. Anesthesiology. 1997;86(2):498–500. doi: 10.1097/00000542-199702000-00027. [DOI] [PubMed] [Google Scholar]
  • 106.Sacks M. D., Marsh D. Bilateral recurrent laryngeal nerve neuropraxia following laryngeal mask insertion: a rare cause of serious upper airway morbidity. Pediatric Anesthesia. 2000;10(4):435–437. doi: 10.1046/j.1460-9592.2000.00550.x. [DOI] [PubMed] [Google Scholar]
  • 107.Theron A. D., Loyden C. Nerve damage following the use of an i-gel supraglottic airway device. Anaesthesia. 2008;63(4):p. 441. doi: 10.1111/j.1365-2044.2008.05507_1.x. [DOI] [PubMed] [Google Scholar]
  • 108.Theron A. D., Loyden C. Nerve damage following the use of an i-gel supraglottic airway device. Anaesthesia. 2008;63(4):p. 441. doi: 10.1111/j.1365-2044.2008.05507_1.x. [DOI] [PubMed] [Google Scholar]
  • 109.McHardy F. E., Chung F. Postoperative sore throat: cause, prevention and treatment. Anaesthesia. 1999;54(5):444–453. doi: 10.1046/j.1365-2044.1999.00780.x. [DOI] [PubMed] [Google Scholar]
  • 110.Scuderi P. E. Postoperative sore throat: more answers than questions. Anesthesia and Analgesia. 2010;111(4):831–832. doi: 10.1213/ane.0b013e3181ee85c7. [DOI] [PubMed] [Google Scholar]
  • 111.Chandler M. Tracheal intubation and sore throat: a mechanical explanation. Anaesthesia. 2002;57(2):155–161. doi: 10.1046/j.1365-2044.2002.02329.x. [DOI] [PubMed] [Google Scholar]
  • 112.Keijzer C., Buitelaar D. R., Efthymiou K. M., et al. A comparison of postoperative throat and neck complaints after the use of the i-gel and the La Premiere disposable laryngeal mask: a double-blinded, randomized, controlled trial. Anesthesia & Analgesia. 2009;109(4):1092–1095. doi: 10.1213/ane.0b013e3181b6496a. [DOI] [PubMed] [Google Scholar]
  • 113.Kihara S., Yaguchi Y., Brimacombe J., Watanabe S., Taguchi N. Routine use of the intubating laryngeal mask air-way results in increased upper airway morbidity. Canadian Journal of Anesthesia. 2001;48(6):604–608. doi: 10.1007/BF03016840. [DOI] [PubMed] [Google Scholar]
  • 114.Joe H. B., Kim J. Y., Kim D. H., Kang M., Chae Y. J., Park K. S. The effect of cuff pressure on postoperative sore throat after Cobra perilaryngeal airway. Journal of Anesthesia. 2012;26(2):225–229. doi: 10.1007/s00540-011-1293-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 115.Roth H., Genzwuerker H. V., Rothhaas A., Finteis T., Schmeck J. The ProSeal laryngeal mask airway and the Laryngeal Tube Suction for ventilation in gynaecological patients undergoing laparoscopic surgery. European Journal of Anaesthesiology. 2005;22(2):117–122. doi: 10.1017/s0265021505000220. [DOI] [PubMed] [Google Scholar]
  • 116.Cook T. M., McCormick B., Asai T. Randomized comparison of laryngeal tube with classic laryngeal mask airway for anaesthesia with controlled ventilation. British Journal of Anaesthesia. 2003;91(3):373–378. doi: 10.1093/bja/aeg192. [DOI] [PubMed] [Google Scholar]
  • 117.Russo S. G., Cremer S., Galli T., et al. Randomized comparison of the i-gel, the LMA Supreme, and the Laryngeal Tube Suction-D using clinical and fibreoptic assessments in elective patients. BMC Anesthesiology. 2012;12, article 18 doi: 10.1186/1471-2253-12-18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 118.Colbert S., O’Hanlon D. M., Page R., Flanagan F., Moriarty D. Haemodynamic changes with the laryngeal mask airway—off the cuff. European Journal of Anaesthesiology. 1997;14(5):514–517. doi: 10.1097/00003643-199709000-00006. [DOI] [PubMed] [Google Scholar]
  • 119.Colbert S.-A., OHanlon D. M., Flanagan F., Page R., Moriarty D. C. The laryngeal mask airway reduces blood flow in the common carotid artery bulb. Canadian Journal of Anaesthesia. 1998;45(1):23–27. doi: 10.1007/BF03011987. [DOI] [PubMed] [Google Scholar]
  • 120.Segal N., Yannopoulos D., Mahoney B. D., et al. Impairment of carotid artery blood flow by supraglottic airway use in a swine model of cardiac arrest. Resuscitation. 2012;83(8):1025–1030. doi: 10.1016/j.resuscitation.2012.03.025. [DOI] [PubMed] [Google Scholar]
  • 121.Nandwani N., Fairfield M. C., Krarup K., Thompson J. The effect of laryngeal mask airway insertion on the position of the internal jugular vein. Anaesthesia. 1997;52(1):77–79. doi: 10.1111/j.1365-2044.1997.012-az012.x. [DOI] [PubMed] [Google Scholar]
  • 122.Nagaraja R. G., Wilson M., Wilson G., Marciniak B., Engelhardt T. The anatomic relationship between the internal jugular vein and the carotid artery in children after laryngeal mask insertion. An ultrasonographic study. Paediatric Anaesthesia. 2011;21(1):62–64. doi: 10.1111/j.1460-9592.2010.03459.x. [DOI] [PubMed] [Google Scholar]
  • 123.Lenoir R. J. Venous congestion of the neck; its relation to laryngeal mask cuff pressures. British Journal of Anaesthesia. 2004;93(3):476–477. doi: 10.1093/bja/aeh603. [DOI] [PubMed] [Google Scholar]
  • 124.Nordin U. The trachea and cuff-induced tracheal injury. An experimental study on causative factors and prevention. Acta Oto-Laryngologica. 1976;345(supplement 1):1–71. [PubMed] [Google Scholar]
  • 125.Cavo J. W., Jr. True vocal cord paralysis following intubation. Laryngoscope. 1985;95(11):1352–1359. doi: 10.1288/00005537-198511000-00012. [DOI] [PubMed] [Google Scholar]
  • 126.Marjot R. Pressure exerted by the laryngeal mask airway cuff upon the pharyngeal mucosa. British Journal of Anaesthesia. 1993;70(1):25–29. doi: 10.1093/bja/70.1.25. [DOI] [PubMed] [Google Scholar]
  • 127.O’Kelly S. W., Heath K. J., Lawes E. G. A study of laryngeal mask inflation. Pressures exerted on the pharynx. Anaesthesia. 1993;48(12):1075–1078. [PubMed] [Google Scholar]
  • 128.Keller C., Brimacombe J., Benzer A. Calculated vs measured pharyngeal mucosal pressures with the laryngeal mask airway during cuff inflation: assessment of four locations. British Journal of Anaesthesia. 1999;82(3):399–401. doi: 10.1093/bja/82.3.399. [DOI] [PubMed] [Google Scholar]
  • 129.Keller C., Brimacombe J., Boehler M., Loeckinger A., Puehringer F. The influence of cuff volume and anatomic location on pharyngeal, esophageal, and tracheal mucosal pressures with the esophageal tracheal combitube. Anesthesiology. 2002;96(5):1074–1077. doi: 10.1097/00000542-200205000-00008. [DOI] [PubMed] [Google Scholar]
  • 130.Brimacombe J., Keller C., Roth W., Loeckinger A. Large cuff volumes impede posterior pharyngeal mucosal perfusion with the laryngeal tube airway. Canadian Journal of Anesthesia. 2002;49(10):1084–1087. doi: 10.1007/bf03017908. [DOI] [PubMed] [Google Scholar]
  • 131.Goldmann K., Dieterich J., Roessler M. Laryngopharyngeal mucosal injury after prolonged use of the ProSeal LMA in a porcine model: a pilot study. Canadian Journal of Anesthesia. 2007;54(10):822–828. doi: 10.1007/bf03021710. [DOI] [PubMed] [Google Scholar]
  • 132.Abud T. M. V., Braz J. R. C., Martins R. H. G., Gregório E. A., Saldanha J. C. High laryngeal mask airway pressures resulting from nitrous oxide do not increase pharyngeal mucosal injury in dogs. Canadian Journal of Anesthesia. 2001;48(8):800–806. doi: 10.1007/bf03016698. [DOI] [PubMed] [Google Scholar]
  • 133.Martins R. H. G., Braz J. R. C., Defaveri J., Gregörio E. A., Abud T. M. V. Effect of high laryngeal mask airway intracuff pressure on the laryngopharyngeal mucosa of dogs. Laryngoscope. 2000;110(4):645–650. doi: 10.1097/00005537-200004000-00020. [DOI] [PubMed] [Google Scholar]
  • 134.Keller C., Brimacombe J. Influence of neuromuscular block, mode of ventilation and respiratory cycle on pharyngeal mucosal pressures with the laryngeal mask airway. British Journal of Anaesthesia. 1999;83(3):480–482. doi: 10.1093/bja/83.3.480. [DOI] [PubMed] [Google Scholar]
  • 135.Ulrich-Pur H., Hrska F., Krafft P., et al. Comparison of mucosal pressures induced by cuffs of different airway devices. Anesthesiology. 2006;104(5):933–938. doi: 10.1097/00000542-200605000-00007. [DOI] [PubMed] [Google Scholar]
  • 136.Miyashiro R. M., Yamamoto L. G. Endotracheal tube and laryngeal mask airway cuff pressures can exceed critical values during ascent to higher altitude. Pediatric Emergency Care. 2011;27(5):367–370. doi: 10.1097/PEC.0b013e318216b0d0. [DOI] [PubMed] [Google Scholar]
  • 137.Mann C., Parkinson N., Bleetman A. Endotracheal tube and laryngeal mask airway cuff volume changes with altitude: a rule of thumb for aeromedical transport. Emergency Medicine Journal. 2007;24(3):165–167. doi: 10.1136/emj.2006.039933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 138.Law J., Bair A., Capra J., Holder A., Allen R. Characterization of airway device cuff volumes at simulated altitude. Aviation, Space and Environmental Medicine. 2011;82(5):555–558. doi: 10.3357/asem.2834.2011. [DOI] [PubMed] [Google Scholar]

Articles from BioMed Research International are provided here courtesy of Wiley

RESOURCES