Table 2.

Multi-hit models for NMTC in the mouse^*

Gene 1	Gene 2	Phenotype
PPFP TX**	Pten KO	Metastatic FTC
K-RasG12D KI	Pten KO	Metastatic FTC
Prkar1a KO	Pten KO	Metastatic FTC
THRBPV/PV	K-Ras KI	ATC
RET-PTC1 TX	Tp53 KO	ATC
RET-PTC3 TX	Tp53 KO	ATC
BRAFV600E TX	Tp53 KO	ATC
Pten KO	Tp53 KO	ATC
BRAFV600E TX	PIK3CAH1047R KI-I	ATC

^*References for each of the models can be found in the text

^**Abbreviations as in Table 1