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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Eur J Pharm Biopharm. 2015 Nov 28;98:108–121. doi: 10.1016/j.ejpb.2015.11.015

Table 6.

Dissolution Statistical Analysis and Coefficients of Regression

Variables % Drug
Release
1 h		 % Drug Release
4 h		 % Drug
Release 12 h		 % Drug Release
18 h
Coefficient P Coefficient P Coefficient P Coefficient P
Model 0.042 0.029 0.019 0.007
Constant 8.10 0.001 24.40 0.000 51.34 0.000 64.05 0.000
X1 1.72 0.149 3.69 0.138 4.79 0.152 4.30 0.103
X2 1.81 0.064 3.72 0.064 4.84 0.072 4.92 0.033
X3 1.58 0.174 2.53 0.262 0.73 0.789 −0.74 0.715
X4 2.00 0.209 5.37 0.130 9.15 0.082 9.66 0.035
X5 2.19 0.040 3.57 0.071 2.77 0.216 1.60 0.310
X6 2.23 0.087 6.14 0.044 10.70 0.024 11.36 0.009
X7 0.67 0.363 −1.13 0.446 −0.64 0.741 −1.75 0.274
R2 = 0.959
Q2 = 0.790		 R2 = 0.894
Q2 = 0.744		 R2 = 0.921
Q2 = 0.665		 R2 = 0.988
Q2 = 0.619

R2: The goodness of fit, Q2: The goodness of prediction