Table 4.
Gene-environment interaction between the polymorphisms and smoking status.
| Interaction | P for interaction | OR (95% CI) | P |
|---|---|---|---|
| NFKB1 ∗ smoking status | 0.31 | ||
| NFKB1 -94 ins/ins ∗ nonsmokers | Ref. | — | |
| NFKB1 -94 ins/del ∗ smokers | 1.01 (0.76–1.33) | 0.96 | |
| NFKB1 -94 del/del ∗ smokers | 0.74 (0.50–1.10) | 0.14 | |
|
| |||
| NFKBIA ∗ smoking status | 0.71 | ||
| NFKBIA -826CC ∗ nonsmokers | Ref. | — | |
| NFKBIA -826CT ∗ smokers | 1.13 (0.80–1.60) | 0.49 | |
| NFKBIA -826TT ∗ smokers | 1.41 (0.35–5.66) | 0.63 | |
|
| |||
| COX-2 ∗ smoking status | <0.01 | ||
| COX-2 (-1195GG) ∗ nonsmokers | Ref. | — | |
| COX-2 (-1195GA) ∗ smokers | 1.29 (0.98–1.69) | 0.07 | |
| COX-2 (-1195AA) ∗ smokers | 1.76 (1.28–2.41) | <0.01 | |
|
| |||
| COX-1 ∗ smoking status | 0.13 | ||
| COX-1 (50CC) ∗ nonsmokers | Ref. | — | |
| COX-1 (50CT) ∗ smokers | 1.46 (0.92–2.32) | 0.11 | |
| COX-1 (50TT) ∗ smokers | 2.38 (0.57–10.00) | 0.24 | |
|
| |||
| PPARG ∗ smoking status | 0.23 | ||
| PPARG Pro/Pro ∗ nonsmokers | Ref. | — | |
| PPARG Pro/Ala ∗ smokers | 0.92 (0.50–1.68) | 0.11 | |
| PPARG Ala/Ala ∗ smokers | N/A | N/A | |
There were two factors involved (polymorphism and smoking status) in each testing; hence, significance is assumed at P < 0.025 after application of Bonferroni correction.