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. 2015 Dec 14;2016:1689602. doi: 10.1155/2016/1689602

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Copyright © 2016 Liming Yu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of berberine and sirtinol treatment on oxidative stress in MI/R-injured heart. Normal SD rats were exposed to BBR treatment (200 mg/kg/d for 2 weeks) in the absence or presence of sirtinol (Stnl, 2 mg/kg/d for 1 week) and then subjected to myocardial ischemia reperfusion (MI/R) operation. Cardiac oxidative stress level was measured after 6 hr of reperfusion. (a) Cardiac superoxide generation. (b) gp91^phox expression. Top images: representative blots. (c) Myocardial MDA contents. (d) Myocardial SOD contents. The results are expressed as the mean ± SEM, n = 8/group. ^∗∗ P < 0.01 versus Sham group, ^## P < 0.01 versus MI/R + V group, and ^$$ P < 0.01 versus MI/R + BBR group.