Table 2.
Results of Meta-analysis Comparison of Laparoscopic Radical Hysterectomy and Abdominal Radical Hysterectomy
| Number of patients | Study heterogeneity | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Outcomes of interest | Number of studies | LRH | ARH | WMD/OR (95% CI) | P valuea | χ2 | df | I2(%) | P valuea |
| Primary outcomes | |||||||||
| 5-year DFSb | 10 | 791 | 1031 | 0.01 (−0.10, 0.11) | .91 | 4.78 | 9 | 0 | .85 |
| 5-year OSb | 6 | 656 | 847 | −0.02 (−0.14, 0.10) | .73 | 4.28 | 5 | 0 | .51 |
| Recurrence rateb | 13 | 924 | 1350 | 0.82 (0.61, 1.11) | .20 | 3.37 | 12 | 0 | .99 |
| Secondary outcomes | |||||||||
| Intraoperative bowel-urinary injury | 17 | 1083 | 1282 | 1.50 (0.99, 2.26) | .06 | 6.79 | 16 | 0 | .98 |
| Perioperative complication | 4 | 315 | 555 | 0.56 (0.36, 0.90) | .02 | 2.50 | 3 | 0 | .47 |
| Postoperative complication | 18 | 1078 | 1451 | 0.75 (0.62, 0.91) | .003 | 40.31 | 16 | 60 | .0007 |
| Intraoperative complication | 10 | 523 | 661 | 1.48 (0.75, 2.91) | .25 | 8.31 | 9 | 0 | .50 |
| Bladder recovery (days) | 3 | 61 | 119 | −2.48 (−5.16, 0.19) | .07 | 17.46 | 2 | 89 | .0002 |
| Anorectal recovery (days) | 4 | 104 | 123 | −0.80 (−1.16, −0.44) | <.00001 | 4.65 | 2 | 57 | .1 |
| Pelvic LNs removed | 16 | 813 | 1220 | −1.44 (−4.14, 1.27) | .3 | 247.44 | 15 | 94 | <.00001 |
| Para-aortic LNs removed | 2 | 73 | 78 | −1.79 (−6.39, 2.82) | .45 | 18.41 | 1 | 95 | <.0001 |
| Operation time (minutes) | 17 | 841 | 1383 | 18.76 (2.13, 35.39) | .03 | 184.15 | 16 | 91 | <.00001 |
| Length of stay (days) | 16 | 1054 | 1437 | −4.36 (−5.38, −3.34) | <.00001 | 141.26 | 15 | 89 | <.00001 |
| Blood loss (mL) | 17 | 1089 | 1481 | −193.61 (−236.80, −150.43) | <.00001 | 80.44 | 16 | 80 | <.00001 |
a
Statistically significant results are shown in bold.
b
Prognostic factors were not significantly different.
ARH, abdominal radical hysterectomy; CI, confidence interval; df, degrees of freedom; DFS, disease-free survival; LN, lymph node; LRH, laparoscopic radical hysterectomy; OS, overall survival; WMD/OR, weighted mean difference/odds ratio.