Table 3.

Results of the Linear Mixed-Effects Models of the Effect of PEP and Ω3 on Mood

Measure	Parameter	Estimate	df	t	p value
KDRS	Intercept	8.65	40.45	4.76	<0.001
	Treatment group (reference: PBO+AM)
	Combined	4.80	38.00	1.81	0.078
	Ω3 monotherapy	−1.18	39.50	−0.44	0.660
	PEP monotherapy	0.34	39.06	0.14	0.891
	Time (weeks)	−0.16	105.08	−0.82	0.413
	Treatment group × time
	Combined × time	−0.707	103.39	−2.63	0.010
	Ω3 monotherapy × time	−0.04	104.20	−0.14	0.887
	PEP monotherapy × time	−0.38	104.60	−1.43	0.155
CDRS-R	Intercept	16.37	34.85	5.61	<0.001
	Treatment group
	Combined	6.60	33.00	1.55	0.131
	Ω3 monotherapy	−1.44	34.12	−0.33	0.741
	PEP monotherapy	−0.56	33.81	−0.14	0.889
	Time	−0.42	104.46	−1.47	0.144
	Treatment group × time
	Combined × time	−0.51	102.96	−1.30	0.197
	Ω3 monotherapy × time	0.19	103.62	0.47	0.639
	PEP monotherapy × time	−0.12	103.93	−0.31	0.758
KMRS	Intercept	9.63	32.06	4.57	<0.001
	Treatment group
	Combined	6.30	29.83	2.06	0.048
	Ω3 monotherapy	1.31	31.30	0.42	0.676
	PEP monotherapy	−0.21	30.97	−0.08	0.941
	Time	−0.61	26.75	−2.05	0.050
	Treatment group × time
	Combined × time	0.34	25.23	0.82	0.419
	Ω3 monotherapy × time	−0.05	26.85	−0.12	0.906
	PEP monotherapy × time	0.04	28.25	0.11	0.916
YMRS	Intercept	18.89	27.57	7.26	<0.001
	Treatment group
	Combined	9.71	26.06	2.56	0.017
	Ω3 monotherapy	2.02	27.08	0.53	0.603
	PEP monotherapy	−0.13	26.83	−0.04	0.971
	Time	−0.52	24.88	−1.76	0.091
	Treatment group × time
	Combined × time	0.12	23.24	−0.30	0.768
	Ω3 monotherapy × time	−0.45	24.57	−1.04	0.310
	PEP monotherapy × time	0.03	26.19	0.07	0.942

Ω3, omega-3; AM, active monitoring; CDRS-R, Children's Depression Rating Scale-Revised; KDRS, Kiddie Depression Rating Scale; KMRS, Kiddie Mania Rating Scale; PBO, placebo; PEP, individual-family psychoeducational psychotherapy; YMRS, Young Mania Rating Scale.