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. 2016 Jan;22(1):61–74. doi: 10.1261/rna.053447.115

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© 2015 Kini et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 3. — PABPC1 binds to a subset of mRNAs at their translation initiation and termination sites. (A) Distribution of PABPC1 CLIP tags along histone mRNA transcripts. Histone mRNAs were binned into 100 evenly sized regions and the CLIP tag coverage in each bin was used to create a composite profile. (B) Screenshots from the UCSC genome browser for two representative histone genes showing CLIP tags proximal the 5′ and 3′ end of the CDS. Green and Red boxes indicate annotated start and stop codons, respectively. (C) Absolute distribution of CLIP tags proximal to the start codon of histone genes. (D) Absolute distribution of CLIP tags proximal to the stop codon of histone genes. (E) Absolute distribution of CLIP tags proximal to the start codon of all mRNAs split into quartiles by 5′ UTR length. (F) Absolute distribution of CLIP tags proximal to the stop codon of all mRNAs split into quartiles by 3′ UTR length.