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. Author manuscript; available in PMC: 2015 Dec 28.
Published in final edited form as: Nat Struct Mol Biol. 2007 Nov 5;14(11):1025–1040. doi: 10.1038/nsmb1338

Figure 7.

Figure 7

Combinations of PTM-binding sites generate different specifities. (a) The double bromodomain motif in hTAF1 simultaneously binds proximal acetylated lysines on H3 or H4. (b) First and second modules of L3MBTL1 may simultaneously bind proline and dimethyllysine marks on histone tails. (c) The PHD finger of BPTF and the proximal bromodomain bind H3K4me3 and an acetyllysine simultaneously.

(d) The PHD finger of Rco1p increases the binding of the Eaf3p chromobarrel to H3K36me3 nucleosomes. (e) Schematic of histone-directed protease activity uncovering a cryptic PTM-binding site.