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. Author manuscript; available in PMC: 2015 Dec 28.
Published in final edited form as: Q Rev Biophys. 2015 Mar 23;48(3):281–322. doi: 10.1017/S003358351400016X

Fig. 3. Structural Tweaking of the Sugar Headgroup Recognition Center in the GLTP-fold to Alter Functional Selectivity for Glycolipids.

Fig. 3

(a–c) Sugar headgroup recognition centers of fungal HET-C2, human GLTP, and human FAPP2–GLTPH showing surface electrostatics. Red and blue indicate negative and positive charge, respectively. In the bound glycolipid ligands (green), oxygen atoms are red. (d) Glycolipid transfer selectivity of fungal HET-C2, human FAPP2–C212, and human GLTP determined by intervesicular transfer of radiolabeled glycolipids as previously described (Brown et al. 1985, 1990)