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. 2015 Dec 1;29(23):2420–2434. doi: 10.1101/gad.271783.115

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© 2015 Pech et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Transcriptional landscape of adult spermatogonial subtypes. (A) Volcano plot of expression profiles comparing Tert^High cKit⁻ with Tert^Low cKit⁺ cells. Genes whose expression significantly differs between the populations are labeled in red (FDR threshold 1%, twofold change threshold). Genes in blue are undifferentiated (A-undiff) markers from the literature. Genes in green are differentiated-biased markers from the literature. The entire list of differentially expressed genes is reported in Supplemental Table S1. (B) Whole-mount analysis of adult seminiferous tubules stained for MSI2 and PLZF. Bar, 50 μm. (C) Whole-mount analysis of adult seminiferous tubules stained for SDC4 and PLZF. Bar, 50 μm. (D) Whole-mount analysis of adult seminiferous tubules stained for ALCAM and PLZF. Bar, 50 μm. B–D represent multiple independent mice. (E) Gene set enrichment analysis (GSEA) of genes up-regulated in Tert^High cKit⁻ or Tert^Low cKit⁺ cells against a database of curated gene sets. Selected significant signatures are shown. The entire GSEA is reported in Supplemental Table S1.