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. 2015 Dec 1;29(23):2463–2474. doi: 10.1101/gad.268961.115

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© 2015 Twaroski et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Identification of FGF-induced immediate early genes. (A) Bar graph showing the impact of cycloheximide on the expression of genes that are classified as being directly regulated by FGFR signaling. Immediate early genes were defined as those whose change in expression was affected by ≤1.5-fold in the presence of cycloheximide (red line). (B) Heat map illustrating the impact of 2.5 µM PD161570 and 100 µM cycloheximide on mRNA levels encoded by genes that are regulated through FGFR signaling. The levels of mRNAs were determined by oligonucleotide array analyses performed on three independently differentiated samples (n = 3 biological replicates) for each condition. (C) Bar graph showing IPA classification of functions (X-axis) associated with 41 genes whose expression was considered an immediate early response to FGFR signaling. The probability of each function (Y-axis) occurring by chance (red line) was determined by Fisher's exact test.