Figure 6. Parallel model of the CXCL8 dimer–dp14 complex.

(A) Interactions of dp14 in subfamily M_2A. Interactions of the core residues and peripheral residues Lys¹⁵ and Lys⁵⁴* (of the second monomer across the dimer interface) are highlighted. (B) Surface plot showing the binding geometry of dp14 in M_2A. (C) Interactions of dp14 in subfamily M_2B showing interactions of the core residues and peripheral residues Lys¹⁵ and Arg⁴⁷. (D) Surface plot showing the orientation of dp14 in M_2B. The basic residues are coloured blue, dp14 is shown as sticks, and the second monomer of the dimer is painted in black.