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. 2016 Jan 1;32(1):93–100. doi: 10.1089/aid.2015.0184

FIG. 3.

FIG. 3.

Peptide triazoles inhibit DC-SIGN-dependent HIV infection. (A) HNG-156, K13, and UM15 show dose-dependent inhibition of the pseudotyped HIV infection of B-THP-1/DC-SIGN cells. Intact virus or virus pretreated with compounds for 30 min was added to the cells, and the rate of viral RNA associated with cells was measured 24 h postinfection. (B) Both 50 μM HNG-156 (HNG) and 100 mM oligodextran (D06) show complementarity in preventing HIV infection of B-THP-1/DC-SIGN cells. (C) In the posttreatment analysis, both were added 20 h postinfection and still decreased infection. Results are given as mean ± SD. The significance of the statistical differences is calculated by Student's t-test and is shown as *p < 0.01.