Table 3.
Inter- and Intraindividual Variability
| Plasma TFV | Plasma FTC | PBMC TFV-DP | PBMC FTC-TP | CD4+ TFV-DP | CD4+ FTC-TP | |
|---|---|---|---|---|---|---|
| Intersubject | ||||||
| 1 tab 1×/wk | 82 (77–92) | 86 (82–105) | 121 (85–171) | 70 (50–88) | 53 (46–92) | 75 (52–91) |
| 1 tab 2×/wk | 41 (36–70) | 49 (34–65) | 61 (47–164) | 78 (68–193) | 46 (26–52) | 64 (52–87) |
| 2 tabs 2×/wk | 60 (42–63) | 48 (32–99) | 49 (32–59) | 54 (44–67) | 51 (29–63) | 53 (26–58) |
| 1 tab daily | 33 (30–49) | 33 (28–54) | 50 (33–66) | 63 (54–81) | 71 (24–87) | 62 (25–86) |
| Intrasubject | ||||||
| 2 tabs 2×/wk | 24 (10–78) | 18 (7–70) | 23 (18–79) | 25 (10–74) | 16 (1–63) | 13 (5–66) |
| 1 tab daily | 17 (6–56) | 14 (8–53) | 34 (14–77) | 32 (21–79) | 55 (11–95) | 65 (10–96) |
Median (range) of CV% of steady state (day 7–day 35) values.
Intersubject variability calculated from CV% for all subjects within a given sample day; median (range) is from among D7, D14, D21, D28, D35 CV%s.
Intrasubject variability calculated from CV% for each subject across all his or her steady-state samples days (D7–D35); median (range) is from among all subjects CV%s. Only higher dose frequency is included due to predominance of BLQ values.