Table 2.
HF and mortality according to baseline high-sensitivity cTnI.a
| Outcome | HR per 1SD increment in log high-sensitivity cTnI values (95% CI) | P | HR for high-sensitivity cTnI values >80th percentile (95% CI) | P |
|---|---|---|---|---|
| HF | ||||
| Unadjusted | 1.91 (1.70–2.15) | <0.0001 | 4.59 (3.48–6.07) | <0.0001 |
| Age and sex | 1.70 (1.47–1.96) | <0.0001 | 3.02 (2.25–4.06) | <0.0001 |
| Model 1 | 1.62 (1.38–1.90) | <0.0001 | 2.56 (1.88–3.50) | <0.0001 |
| Model 2 | 1.33 (1.04–1.69) | 0.023 | 1.43 (0.92–2.28) | 0.114 |
| Model 3 | 1.42 (1.20–1.68) | <0.0001 | 2.04 (1.46–2.83) | <0.0001 |
| Mortality | ||||
| Unadjusted | 1.79 (1.64–1.96) | <0.0001 | 4.17 (3.35–5.19) | <0.0001 |
| Age and sex | 1.43 (1.26–1.62) | <0.0001 | 2.12 (1.67–2.68) | <0.0001 |
| Model 1 | 1.36 (1.18–1.56) | <0.0001 | 1.91 (1.49–2.46) | <0.0001 |
| Model 2 | 1.12 (0.90–1.39) | 0.330 | 1.53 (1.07–2.17) | 0.019 |
| Model 3 | 1.15 (0.98–1.33) | 0.075 | 1.41 (1.08–1.85) | 0.012 |
a
Model 1 was adjusted for age, sex, systolic blood pressure, creatinine (log), BMI, smoking status, and presence of hypertension, diabetes, and coronary artery disease. Model 2 was adjusted for all variables in Model 1 plus ejection fraction <50%, moderate/severe diastolic dysfunction, left ventricular hypertrophy, left atrial enlargement, and presence of wall motion abnormalities. Model 3 was adjusted for all variables in Model 1 plus NT-proBNP.