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Size dependence of GNP uptake and sensitization. A) Cellular uptake of GNPs with a diameter size of 10-100 nm. B) Cell survival curves based on a clonogenic assay for the same cells as in A. C) Cells that internalized GNPs showed more DNA double strand breaks after radiation compared to the control cells with no internalized GNPs. D) Schematic showing enhanced free radial formation during the radiation treatment in the presence of GNPs (reprinted with permission) (20, 21, 24).
