Pharmacokinetics and biodistribution of 2, 6, and 15 nm GNPs coated with tiopronin. A) Blood elimination profiles of gold following a single intravenous injection of GNPs at a dose of 5 mg gold/kg in tumor-bearing mice. Data represent mean ± SD (n = 3). B) Gold content in tumor, heart, liver, spleen, lung, brain, and kidney 24 h after intravenous injection of GNPs at 5 mg gold/kg. Data represent mean ± SD (n = 3) C) Representative TEM micrographs of tumor tissue taken 24 h after the administration of GNPs. Figure with permission from (33).