FIGURE 4.

Visualization of significantly altered lipid pathway changes in EAE. A, lipids found significantly down-regulated in EAE (p < 0.05) are shown as blue nodes, and up-regulated lipids are shown in yellow. Unchanged and undetected lipids are shown as white and gray nodes, respectively. B, metabolite enrichment pathway (Metaboanalyst 3.0) overview highlights PUFAs being significantly enriched in the metabolomic profile of plasma of EAE versus control. C, ω-3 and ω-6 PUFAs are highlighted, and key metabolites in the plasma of vehicle control and EAE groups are presented as a bar graph (n = 5). p < 0.05 is considered significant.