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Telomerase deficiency induced telomere shortening and TIFs in isolated AECII population. A and B, distributions of telomere length in AECII determined by quantitative FISH and expressed as mean telomere fluorescence of each isolated AECII. C, micrographs of peptide nucleic acid probe-labeled telomeres, 53BP1 antibody-labeled damaged DNA, and co-localized telomere and 53BP1 foci. D and E, mean counts for isolated AECII with each cell containing more than two TIFs. Error bars, S.E.
