FIGURE 6.

TERC or TERT deficiency resulted in reduced gene expression of TGF-β1 and canonical receptors in pulmonary tissues. A–C, the mRNA levels of TGF-β1 (A), TGFβRII (B), and TGFβRI (C) were determined by quantitative real-time PCR from at least four animals, as indicated. D–F, the mRNA levels of BMPRII (D), BMPRIa (E), and BMPRIb (F) were determined by quantitative real-time PCR from at least four animals, as indicated. G, TGFβ1 levels detected by ELISA using specific antibodies from BAL fluid of TERC-null mice. H and I, IL-6 and CXCL15 levels measured by ELISA from BAL fluid of TERC-null mice. J and K, IL-6 and CXCL15 levels measured by ELISA from BAL fluid of TERT-null mice. All data are the mean ± S.E. (error bars) of multiple representative experiments.