FIGURE 8.

TERC deficiency resulted in inflammatory cell infiltration in pulmonary tissues. A, TERC deficiency induced increases in CD45-positive mononuclear cells. The left bar graph shows summarized data presented as the mean ± S.D. (error bars) from three flow cytometric analyses. The middle and right panels are representative plots of cell distributions labeled by Percp-cy5.5-CD45 but not by EpCAM. B, TERC deficiency induced increases in CD16/32-positive mononuclear cells. The left bar graph shows summarized data presented as mean ± S.D. from at least three animals. The middle and right panels are representative plots of cell distributions labeled by APC-CD11b. C, TERC deficiency induced increases in CD11b-positive mononuclear cells. The left bar graph shows summarized data presented as mean ± S.D. from at least three animals. The middle and right panels are representative plots of cell distributions labeled by FITC-F1/80, PE-NK1.1, and APC-CD11c (D–F). TERC deficiency resulted in no changes in the ratios of macrophages (D), NK cells (E), or dendritic cells (F) by flow cytometry.