FIGURE 4.

Altered Tau 3R and 4R expression in Tat-transgenic mice. A, diagram showing the six Tau isoforms originated from the alternative splicing of exons 2, 3, and 10 (modified from Ref. 7). Inclusion of exon 10 results in a Tau that possesses four tubulin-binding domains (4R), whereas exclusion results in three tubulin-binding domains (3R). The fully spliced 0N 3R is also called fetal Tau. B and C, expression of Tau 3R and 4R in the hippocampus, prefrontal cortex, and cortex without PFC of brains from Tat-tg mice in which expression of Tat was induced (Tat⁺) or in mice lacking the Tat transgene (Tat⁻).