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Rv2466c mediates the reduction of TP053 to kill M. tuberculosis. Model of the catalytic cycle of Rv2466c. Reduced Rv2466c reacts with TP053 to oxidized Rv2466c and reduced reaction products. Oxidized Rv2466c is then recycled to its reduced form by reduced DTT via disulfide exchange. The proposed electron flow during redox exchange is indicated in red. MIC, minimum inhibitory concentration.
