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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: IJC Metab Endocr. 2015 Nov 24;10:16–23. doi: 10.1016/j.ijcme.2015.11.003

Figure 6.

Figure 6

A schematic summary of the results. Mast cell activators are released from myocardial cells in response to TAC. Upon activation, cardiac mast cells release tryptase and chymase into the interstitium. Released tryptase acts in an autocrine fashion to activate mast cells and thus further increase tryptase and chymase release. Nedocromil prevents mast cell tryptase and chymase release while nafamonstat mesilate prevents tryptase-induced mast cell activation. The fact that chymostatin completely prevents TAC-induced fibrosis indicates that the myocardial levels of tryptase are insufficiently elevated to directly stimulate fibroblast collagen production.