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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Immunity. 2015 Dec 15;43(6):1053–1063. doi: 10.1016/j.immuni.2015.11.007

Figure 3. The HIV-1 SOSIP Env trimer structure at 3.0 Å resolution.

Figure 3

(A) Ribbon representation of gp41 in the context of the BG505 SOSIP.664 trimer. The gp120 subunits are shown in surface representation while gp41 is shown in ribbon representation. (B) Ribbon representation of one protomer with the new region of 20 residues, located within the HR1 helix, and connecting the I548 and I568 residues, highlighted with a yellow surface. The position of the I559P mutation in the trimer is also indicated. On the right hand side is an enlarged image of the region between residues I548 and I568 (in red) and a 2Fo-Fc electron density map contoured at 0.5σ (yellow mesh). (C) Detailed representation of mutations introduced into the gp41 structure to stabilize the SOSIP.664 trimer.

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