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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Curr Osteoporos Rep. 2015 Oct;13(5):327–335. doi: 10.1007/s11914-015-0286-8

Figure1. Mechanisms of diabetes-increased osteoclastogenesis.

Figure1

Diabetes leads to hyperglycemia, enhanced and prolonged inflammation, formation of AGEs and generation of ROS. This dysregulation as well as reduced insulin signaling may lead to increased osteoclast formation, particularly when bone is challenged by wounding, bacteria induced inflammation or other events that disrupt homeostasis. This dysregulation may lead to an increased RANKL/OPG ratio or affect osteoblasts through other mechanisms to increase bone resorption.