Fig 8. A. Setdb2 expression by Mϕ influences antigen-specific cytokine production by CD4⁺ T cells.

(A) CD4⁺ T cells isolated from OT-II mice were cultured with ovalbumin peptide in the absence or presence of control or Setdb2 ^-/- BM-Mϕ. The concentration of IL-2, IL-4, IL-5, IL-10, IL-17, and IFN-γ in supernatants was measured 48 hours after plating. Values represent mean ± SEM from 3–4 independent experiments. *p<0.05; **p<0.01; ***p<0.001.