Fig. 1.

(A) Schematic representation of the Aβ_1-42 peptide sequence. The arrows show the reported engagement of different parts of the sequence in the mature amyloid fibrils [24], [25], [26], [27], [28], with the unstructured N-terminus marked in green and the β-sheet regions participating in the core marked in orange. Tyr₁₀ is highlighted in red. (B) Atomic force microscopy image of oAβ_1-42. (C–D) TEM image of oAβ_1-42 at higher magnification. (E) TEM image of fAβ_1-40. (F) TEM image of fAβ_1-42. (G) TEM image of mAβ_1-40 showing the absence of aggregates in the monomeric preparation. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)