Table 2. Single-locus genotype distributions of IS and its subtypes.
| Genotypes | Stroke | ||||
|---|---|---|---|---|---|
| Controls | Total | LAA | SAO | CE | |
| (n = 774) | (n = 712) | (n = 327) | (n = 221) | (n = 54) | |
| ACE I/D | 0.024* | 0.355* | 0.024* | 0.489* | |
| DD (%) | 64 (8.3) | 74 (10.4) | 32 (9.8) | 26 (11.8) | 4 (7.4) |
| ID (%) | 351 (45.3) | 356 (50.0) | 158 (48.3) | 114 (51.6) | 29 (53.7) |
| II (%) | 359 (46.4) | 282 (39.6) | 137 (41.9) | 81 (36.7) | 21 (38.9) |
| β-FG T148C | 0.026* | 0.069* | 0.028* | 0.664* | |
| TT (%) | 77 (9.9) | 29 (8.9) | 29 (8.9) | 15 (6.8) | 4 (7.4) |
| CT (%) | 301 (38.9) | 243 (34.1) | 106 (32.4) | 71 (32.1) | 24 (44.4) |
| CC (%) | 396 (51.2) | 413 (58.0) | 192 (58.7) | 135 (61.1) | 26 (48.1) |
| β-FG A455G | 0.053* | 0.084* | 0.050* | 0.732* | |
| AA (%) | 62 (8.0) | 46 (6.5) | 23 (7.0) | 12 (5.4) | 4 (7.4) |
| GA (%) | 302 (39.0) | 245 (34.4) | 107 (32.7) | 72 (32.6) | 24 (44.4) |
| GG (%) | 410 (53.0) | 421 (59.1) | 197 (60.2) | 137 (62.0) | 26 (48.1) |
| MTHFR C677T | 0.743* | 0.854* | 0.866* | 0.761* | |
| TT (%) | 52 (6.7) | 55 (7.7) | 25 (7.6) | 17 (7.7) | 5 (9.3) |
| CT (%) | 299 (38.6) | 269 (37.8) | 124 (37.9) | 86 (38.9) | 21 (38.9) |
| CC (%) | 423 (54.7) | 388 (54.5) | 178 (54.4) | 118 (53.4) | 28 (51.9) |
| ApoE ε2–4 | 0.841* | 0.396* | 0.919* | 0.503* | |
| ε2ε2 (%) | 3 (0.4) | 4 (0.6) | 2 (0.6) | 1 (0.5) | 1 (1.9) |
| ε2ε3 (%) | 107 (13.8) | 93 (13.1) | 35 (10.7) | 36 (16.3) | 6 (11.1) |
| ε2ε4 (%) | 8 (1.0) | 13 (1.8) | 7 (2.1) | 2 (0.9) | 1 (1.9) |
| ε3ε3 (%) | 535 (69.1) | 494 (69.4) | 225 (68.8) | 152 (68.8) | 38 (70.4) |
| ε3ε4 (%) | 113 (14.6) | 101 (14.2) | 54 (16.5) | 28 (12.7) | 8 (14.8) |
| ε4ε4 (%) | 8 (1.0) | 7 (1.0) | 4 (1.2) | 2 (0.9) | 0 (0.0) |
| eNOS G894T | 0.622* | 0.577* | 0.671* | 0.281* | |
| TT (%) | 12 (1.6) | 14 (2.0) | 8 (2.4) | 5 (2.3) | 0 (0.0) |
| GT (%) | 143 (18.5) | 142 (19.9) | 62 (19.0) | 44 (19.9) | 14 (25.9) |
| GG (%) | 619 (80.0) | 556 (78.1) | 257 (78.6) | 172 (77.8) | 40 (74.1) |
LAA, large artery atherosclerosis; SAO, small-artery occlusion; CE, cardioembolism.
*P-values are based on chi-square test for genotype comparison.