Table 4. Impact of interaction between ACE I/D and β-FG T148C on IS and its subtypes.

	High-risk combination (%)	Low-risk combination (%)	Adjusted OR* (95% CI)	P-value*
Controls	233 (30.1)	542 (69.9)
Overall IS	288 (40.4)	424 (59.6)	1.57(1.22–2.02)	<0.0001
Stroke subtypes
LAA	129 (39.4)	198 (60.6)	1.50(1.08–2.07)	0.016
SAO	99 (44.8)	122 (55.2)	2.04(1.43–2.91)	<0.0001

OR, odds ratio; CI, confidence interval; IS, ischemic stroke; LAA, large artery atherosclerosis; SAO, small-artery occlusion.

*Adjusted for age, sex, family history of IS, hypertension history and history of DM.