Table 1.

Symptoms of allergies to medicines according to Gell and Coombs [20, 22]

Gell and Coombs reaction type	Time to onset of response	Examples of symptoms
I	Up to 10–30 min	Anaphylactic shock, asthmatic attack, angioedema, some urticaria
II	After 50 min, but usually after 3 days	Erythema after penicillin, hemolytic anemia
III	After 3–5 days	Some urticaria, drug fever, vasculitis, hepatitis
IV	After 7 days	Contact dermatitis