Table 6.
Putative targets of miRNAs upregulated in metastatic melanoma.
| Genes | miR-17 | miR-19a | miR-149 | miR-21 | |
|---|---|---|---|---|---|
| ADD3 | adducin 3 (gamma) | y | |||
| ARL4C | ADP-ribosylation factor-like 4C | y | |||
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | y | y | ||
| BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein) | y | y | ||
| CD34 | CD34 molecule | y | |||
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | y | |||
| CXCL12 | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | y | |||
| CYBB | cytochrome b-245, beta polypeptide | y | |||
| DSC3 | desmocollin 3 | y | |||
| EREG | epiregulin | y | y | ||
| ESR1 | estrogen receptor 1 | y | y | ||
| FAT2 | FAT tumor suppressor homolog 2 | y | |||
| FBLN1 | fibulin 1 | y | y | ||
| GJA1 | gap junction protein, alpha 1, 43 kDa | y | y | ||
| GRHL2 | grainyhead-like 2 (Drosophila) | y | |||
| HLF | hepatic leukemia factor | y | y | ||
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | y | |||
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | y | y | ||
| LRRK1 | leucine-rich repeat kinase 1 | y | |||
| LTB4R | leukotriene B4 receptor | y | |||
| MACF1 | microtubule-actin crosslinking factor 1 | y | |||
| MBNL1 | muscleblind-like (Drosophila) | y | y | y | |
| MGEA5 | meningioma expressed antigen 5 (hyaluronidase) | y | |||
| MPZL2 | myelin protein zero-like 2 | y | |||
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | y | |||
| NLRP3 | NLR family, pyrin domain containing 3 | y | |||
| NMT2 | N-myristoyltransferase 2 | y | |||
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | y | y | ||
| PAIP2B | poly(A) binding protein interacting protein 2B | y | y | ||
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | y | |||
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | y | |||
| RAPGEFL1 | Rap guanine nucleotide exchange factor (GEF)-like 1 | y | y | ||
| RORA | RAR-related orphan receptor A | y | y | y | |
| RTN1 | reticulon 1 | y | |||
| TCF4 | transcription factor 4 | y | |||
| TMEM45A | transmembrane protein 45A | y | |||
| TNFRSF25 | tumor necrosis factor receptor superfamily, member 25 | y | |||
| TP63 | tumor protein p63 | y | y | ||
| TXNIP | thioredoxin interacting protein | y | |||
| ZFP36L2 | zinc finger protein 36, C3H type-like 2 | y |
No binding sites of miR-126 were found in the 3′-UTRs of the genes associated with melanoma progression.