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Synthetic lethal interaction of cytochrome oxidase genes. (a) Shows the SL3 landscape with in silico SL3 interactions between sdhD, dhoDh and 18 different cox genes. (b) Shows the reactions that get knocked out upon in silico removal of dhoDh, sdhD and either of the 18 cox(N) genes, preventing synthesis of cofactors FAD and FADH2. (c) Shows why the absence of FAD prevents the sphinganine to sphingosine conversion (shown in red) making the removal of gene triplet lethal.
