Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overall workflow of the method with breakpoint selection as the first step followed by the main optimization and used optimizers in parentheses. The model inputs are successively expanded as described on the left columns. The first two steps only use the concentration observables, whereas the final step additionally incorporates the enrichment observables from the 13C tracer.
