Table 1.
Structure of breakpoint junctions for ALK, ROS1, and RET reciprocal fusions in lung adenocarcinoma.
| Onco-gene | Sample name | Partner gene | Nucleotide deletion | DNA segment duplication | Mode of DNA end joining | Smoking | ||
|---|---|---|---|---|---|---|---|---|
| Kinase | Partner | Kinase | Partner | |||||
| ALK | L07K165_T | EML4 | 4-bp | 17-bp | - | - | NHEJ | No |
| AD09-357T | EML4 | 4-bp | - | - | - | NHEJ | No | |
| L07K154_T | EML4 | - | - | - | - | NHEJ | No | |
| AD09-055T | EML4 | - | - | 54-bp | - | SDEJ | No | |
| ROS1 | 103T | CD74 | - | 32-bp | 41-bp | - | SDEJ | No |
| RET | BR0020 | KIF5B | - | - | - | - | NHEJ | No |
| L07K201T | KIF5B | 15-bp | 19-bp | - | - | NHEJ | Yes | |
| 349T | KIF5B | 1-bp | 7-bp | - | - | NHEJ | Yes | |
| AD08-341T | KIF5B | 16-bp | 26-bp | - | - | NHEJ | No | |
| RET-024 | CCDC6 | 14-bp | 2-bp | - | - | NHEJ | Yes | |
| RET-030 | CCDC6 | 52-bp | 1021-bp | - | - | NHEJ | No | |
| AD12-106T | KIF5B | - | 573-bp | 490-bp | - | SDEJ | Yes | |
| BR0030 | KIF5B | - | - | - | 211-bp | SDEJ | No | |
| 442T | KIF5B | 269-bp | - | - | 235-bp | SDEJ | No | |
| AD08-144T | KIF5B | 7-bp | - | - | 2576-bp | SDEJ | No | |