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Functional interaction between p53 family and RUNX family. In response to DNA damage, RUNX1 and RUNX3 assist p300-mediated acetylation of p53 at Lys-373/382 and p-ATM-mediated phosphorylation of p53 at Ser-15, respectively, and then augment its pro-apoptotic activity. In contrast, RUNX2 is associated with HDAC6, and thereby prohibits pro-apoptotic activity of p53 through its deacetylation.
