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. 2015 Nov 20;5(4):3204–3259. doi: 10.3390/biom5043204

Figure 2.

Figure 2

Schematic representation of DNA repair by homologous recombination. During Homologous Recombination (HR), the double-strand break is recognized by the MRE11-RAD50-NBS1 (MRN) (MRE11-RAD50-NBS1) complex, which resects DNA (with EXO1, CtIP and BLM) to create a 3'-overhang DNA that will be protected by RPA. The BRCA1-PALB2-BRCA2 complex then mediates the replacement of RPA by RAD51. RAD51 nucleoprotein filament, invades the complementary DNA template (a step called strand invasion), leading to the formation of the Displacement-loop (D-loop) structure. Following branch migration and resolution, faithful DNA repair occurs.