Table 1.

Involvement of cathepsin D in the stages of tumor progression in different cancer types.

Cancer Type	Metastasis	Invasion	Angiogenesis	References
Breast	↑	↑	↑	[45,46,47,48]
Ovarian	ND	ND	↑	[18]
Prostate	↑	↑	↓	[49,50,51]
Endometrial	ND	↑	ND	[58]
Melanocytic	↑	↑	ND	[53]
Glioma	↑	↑	ND	[54]
Lung	ND	↑	ND	[57]

↑, increase in effects; ↓, reduction in effects; ND, not determined.