Table 2.
Effects on nociceptive pain and itch of various types of VGLUT deletion (Reductions are shown in red, lack of change are shown in black and dashes show pain modalities that have not been assessed; concomitant actions with neuropeptides are shown in purple; # Brumovsky, unpublished data; * Yes, when concomitant pharmacological blockade of SP).
| Nociceptive Pain | Itch | ||||||
|---|---|---|---|---|---|---|---|
| Thermal | Mechanical | Visceral | |||||
| Tail Withdrawal | Hot Plate | Hargreaves | Acetone, Cold ethanol, Dry ice pellet | Randall-Sellito | Von Frey | ||
| Global KO | |||||||
|
VG1 (+/−) [40] |
VG1 (+/−) [40] |
— | — | — |
VG1 (+/−) [40] |
VG1 (+/−) [40] |
— |
|
VG2 (+/−) [40,41] |
VG2 (+/−) [40,41] |
VG2 (+/−) [40,41] |
— | — |
VG2 (+/−) [40] |
VG2 (+/−) [40] |
— |
| — |
VG3 (−/−) [30,31] |
VG3 (−/−) [30] |
VG3 (−/−) [30,31] |
VG3 (−/−) [30] |
VG3 (−/−) [30,31] |
VG3 (−/−) # | — |
| Targeted KO | |||||||
|
VG2-DRG [26] |
— |
VG2-DRG [26] |
— |
VG2-DRG [26] |
VG2-DRG [26] |
— |
VG2-DRG [26] |
|
VG2-nocicept. [25] |
VG2-nocicept. [25] |
VG2-nocicept. [25] |
VG2-nocicept. [25] |
VG2-nocicept. [25] |
VG2-nocicept. [25] |
— |
VG2-nocicept. [25] |
| — | — |
VG2-TRPV1 [6,28,38] |
VG2-TRPV1 * [38] |
VG2-TRPV1 [6] |
VG2-TRPV1 [6,28,38] |
— |
VG2-TRPV1 [6,28,38] |
| — |
VG2- TH [6] |
VG2 –TH [6] |
— |
VG2 –TH [6] |
VG2 –TH [6] |
— |
VG2-TH [6] |
| — |
VG2-Nav1.8 [27] |
VG2-Nav1.8 [6,27] |
VG2-Nav1.8 [27] |
VG2-Nav1.8 [27] |
VG2- Nav1.8 [27] |
— |
VG2-Nav1.8 [6,27] |
| — | — |
VG3-DRG [33] |
— |
VG3-DRG [33] |
VG3- DRG [33] |
— | — |
VG1 (+/−), VGLUT1-KO; VG2 (+/−), VGLUT2-KO; VG3 (−/−), VGLUT3-KO; VG2-DRG, VGLUT2-DRG-KO; VG2-nocicept., VGLUT2-nociceptors-KO; VG2-TRPV1, VGLUT2-TRPV1-KO; VG2-TH, VGLUT2-TH-KO; VG2-Nav1.8, VGLUT2-Nav1.8-KO; VG3-DRG, VGLUT3-DRG-KO.