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Signaling mechanisms downstream of presynaptic NMDA receptor activation. Presynaptic NMDARs control spontaneous glutamate release, timing-dependent LTD and pattern-dependent LTD through three distinct signaling pathways. Facilitation of spontaneous release does not depend on calcium influx. Timing-dependent LTD appears to require coincident activation of presynaptic CB1 receptors and glutamate release from astrocytes.
