| Authors, year | Country | Age | Sex | Symptoms and clinical signs | ALT/AST (UI/L) | GGT/ALP (UI/L) | TB (DB) (mg/dL) | WBC (x 109/L) | L (atypical) (%) | CRP (mg/L) | Ultrasonographic findings in the GB | Antibiotic | Surgery |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yoshie et al., 20048 | Japan | 15 | F | Fever, abdominal pain (positive MS), cervical adenopathy, splenomegaly | 569/215 | -/- | -(-) | 11 | 73 (-) | Wall thickening (10 mm) | - | - | |
| Lagona et al., 20079 | Greece | 4 | F | Fever (4 d), malaise, vomiting, abdominal pain (positive MS), hepatosplenomegaly, scleral icterus, exudative tonsillopharyngitis, cervical adenopathy | 304/188 | 241/236 | 4.6 (3.6) | 22.1 | - (25) | 8 | Wall thickening (9 mm), sludge, positive SMS | No | No |
| Prassouli et al., 200710 | Greece | 13 | F | Fever (5 d), malaise, vomiting, RUQ abdominal pain (positive MS), jaundice, pharyngitis, hepatomegaly, splenomegaly*, exudative tonsillopharyngitis*, cervical adenopathy* | 674/394 | 352/721 | 4 (3.5) | 13.8 | 53(15) | 37 | Wall thickening (13.6 mm), intramular striations, sludge, positive SMS | Yes (7d) | No |
| Gora-Gebka et al., 200811 | Poland | 9 | F | Fever (6 d), malaise, abdominal pain (positive MS), hepatosplenomegaly, pharyngitis, cervical adenopathy, diarrhea, petechial rash (limbs), jaundice | 179/- | 182/629 | 4.65 (2.5) | 21.2 | 44 (-) | 47.3 | Wall thickening (9 mm), intramural striations, pericholecysticfluid collection | Yes | No |
| Gora-Gebka et al., 200811 | Poland | 4 | F | Fever (7 d), RUQ abdominal pain, jaundice, hepatosplenomegaly, | 423/388 | 301/752 | 2.89 (1.6) | 25.9 | 22(62) | 18.8 | Wall thickening (7 mm), intramural striations acholic stools | Yes | No |
| Pelliccia et al., 200812 | Italy | 14 | F | Fever, cervical adenopathy, pharyngitis, abdominal pain (positive MS), hepatosplenomegaly | 108/- | -/- | -(-) | - | 72 (-) | - | Wall thickening (10 mm) | No | No |
| Attilakos et al., 200913 | Greece | 5 | M | Fever (7 d), sore throat, malaise, scleral icterus, exsudative tonsillopharyngitis, cervical adenopathy, hepatosplenomegaly | 257/207 | 333/919 | 1.8 (0.9) | 23.3 | - (10) | 13 | Wall thickening (4.2 mm), striations, positive SMS | No | No |
| Attilakos et al., 200913 | Greece | 4 | F | Fever (4 d), malaise, vomiting, RUQ abdominal pain, scleral icterus, exsudative tonsillopharynghitis, cervical adenopathy, hepatosplenomegaly | 304/188 | 241/236 | 4.6 (3.6) | 22.1 | - (25) | 8 | Wall thickening (9 mm), sludge, positive SMS | No | No |
| Arya et al., 20107 | USA | 16 | F | Fever (7 d), malaise, vomiting, RUQ abdominal pain (positive MS), jaundice, pharyngitis, exudative tonsillopharyngitis* | 479/211 | 173/458 | 8.5 (5.2) | 13.2 | - (81) | - | Wall thickening (9 mm), pericholecystic edema | Yes* | No |
| Aydin Teke et al., 201314 | Turkey | 8 | F | Fever (7 d), vomiting, RUQ abdominal pain, exudative tonsillopharyngitis, cervical adenopathy, hepatosplenomegaly | 496/569 | 103/434 | 4.6 (3.2) | 10.2 | 74 (-) | - | Wall thickening, GB distention | No | No |
| Fretzayas et al., 201415 | Greece | 11 | F | Fever (2 d), facial edema (eyelids), pharyngitis, hepatosplenomegaly, cervical adenopathy, positive MS* | 198/291 | 52/536 | 1.8 (0.4) | 14.6 | 70 (-) | 5 | Wall thickening (7.3 mm) | - | No |
| Fretzayas et al., 201415 | Greece | 12 | F | Fever (3 d), coryza, cough, abdominal pain, hepatosplenomegaly, facial edema (eyelids) | 125/134 | 162/- | -(-) | 4.9 | 53 (-) | 11 | Wall thickening (9 mm), striations, sludge | - | No |
| Kim et al, 20146 | Korea | 10 | F | Fever (1 d), malaise, RUQ abdominal pain (positive MS), cervical adenopathy | 489/311 | 308/- | 1 (0.6) | 8.2 | 56(1) | 4 | Wall Thickening (6 mm), positive SMS | Yes | No |
| Poddighe et al., 201416 | Italy# | 7 | F | RUQ abdominal pain (positive MS), hepatomegaly, vomiting, jaundice, pharyngitis | 3324/3398 | 143/- | 8.9 (5.06) | 8.5 | - (-) | 3.5 | Wall thickening (10 mm), sludge, pericolecystic | fluidYes* | No |
| Suga et al., 201417 | Japan | 6 | F | Fever (10 d), facial edema (eyelids), cervical adenopathy, pharynghitis, abdominal pain (positive MS) | 139/184 | 36/506 | 0.4 (0.1) | 13.6 | - (-) | 6 | Wall thickening (4.6 mm), sludge, pericholecystic fluid, positive SMS | Yes | No |
| Alkhoury et al., 201518 | USA | 15 | F | Fever (3 d), malaise, vomiting, abdominal pain, cough, headache | 221/191 | -/221 | 2.3 (1.8) | 10.9 | 59 (-) | - | Wall thickening (19 mm), pericholecystic fluid | No | No |
| Shah et al., 201519 | USA | 6 | M | Fever (6 d), malaise, vomiting, abdominal pain (positive MS), splenomegaly | 331/135 | 180/569 | 2.3 (1.5) | 18.2 | 80 (-) | - | Wall thickening (8 mm), GB distention, sludge | Yes (8d) | No |
| Present case | Portugal | 16 | F | Fever (8 d), facial edema (periorbital), malaise, RUQ abdominal pain, cervical adenopathy, hepatomegaly*, exudative tonsillopharyngitis* | 409/721 | 330/365 | 0.7 (0,3) | 10.1 | 61(13) | 7.1 | Wall thickening (9 mm), GB distention, striation | Yes* | No |
ALT: alanine aminotransferase, ALP: alkaline phosphatase, GGT: Gamma-glutamyltransferase; ALP: alkaline phosphatase; TB: total bilirubin; DB: direct bilirubin; WBC: white blood cells, L: Lymphocytes, CRP: C-reactive protein; GB: gallbladder; F:female; M: male; MS: Murphy’s sign; d: days; RUQ: right upper quadrant; SMS: sonographic Murphy’s sign
*Symptoms and clinical signs developed during hospital stay; discontinued after diagnosis of primary Esptein-Barr virus infection
#Born in Parkistan.