Table 3.

Analysis of neutropenia across all treatments (classification National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) grade ≥1 vs. grade 0)

Toxicity	n (univariable analysis)	n (multivariable analysis)	BCSS				RFS
			Unadjusted		Adjusted		Unadjusted		Adjusted
			HR (95 % CI)	P value	HR (95 % CI)	P value	HR (95 % CI)	P value	HR (95 % CI)	P value
Neutropenia	5,886	5,211	0.86 (0.77–0.96)	0.009	0.87 (0.77–0.99)	0.03	0.91 (0.83–0.99)	0.04	0.91 (0.82–1.01)	0.07

BCSS Breast cancer-specific survival; RFS Relapse-free survival; HR Hazard ratio; CI, Confidence interval